Until recently, Doreen's PD medication regimen had been: Sinemet (25/100)...7:00 w/Amantadine 100 mg...10:30 w/Amantadine 100 mg...3:30, Sinemet only...5:00, Sinemet only. Approximately one week ago, this was changed to: 1 Sinemet, every 2 hours starting with 7:00 a.m. This was the prescribed regimen with the "less, more frequent" dosage as a trial hoping to decrease the dyskinesia(s) associated with the Sinemet. Her "neuro"...in an attempt to decrease the number of times she was taking the Sinemet, i.e., every 2 hours, has now prescribed Sinemet CR (still with the Amantadine with the first two doses) and NO regular Sinemet...just the Sinemet CR. I would so appreciate your input related to eliminating the regular Sinemet and substituting Sinemet CR. What has been your experience? How have you taken the Sinemet CR?

Thank you for any help you may be able to give me.

Therese

My personal experience was that the Sinemet CR did not have enough "oomph!" at the beginning of the dose to reach a level to ever kick in. Maybe is they came up with a higher dosage of the CR, it would be more helpful for some. I know there are others on the site who find it very helpful.

Maybe this would be a good question for "Ask the Doctor" at the National Parkinson web site.

Peace to you,
Vicky

http://www.vivo.colostate.edu/hbooks.../foodchem.html

it all boils down to can she eat -the ability to breakdown her food and break down the chemical they made called synthetic el dopa?
because the theory is we do not make dopamine anymore?
or is she still making some dopamine/ and the drugs are too much on her
system - that is why this and othr illnesses are so individual -
we are not alike -we are not clones, we have many different deficiences
minerals, vitamins, enzymes amino acids...
our blood types etc.
http://www.vivo.colostate.edu/hbooks...s/gi_bugs.html
also she can not multitask -it is shorting out her nervous system.
take care my dear...

ps: is she constipated? nice Q:? hmmm. very important Q: however...

The CR made me more dyskinetic. I prefer taking 25/100s more frequently - i feel like i am more in control.

paula

I have had to move my doses closer together due to wearing off and having very uncomfortable dystonia. I take Sinemet every 3 hours along with requip and amantadine. I have tried the CR going to bed, Dr. thought it might get me through the night. I found it upset my stomach and didn't help much to get me through the night. I can see using it as well as the fast acting Sinemet but I wouldn't want to use it alone. The yellow zingers work best for me.

To those of you who take Sinemet CR, is it taken as an adjunct to the "regular" Sinemet or as monotherapy, i.e., as a supplement to the "regular" Sinemet? If you are taking Sinemet CR as a monotherapy, would you please give me your dosing schedule? If you're taking Sinemet CR as an adjunct to the "regular" Sinemet, would you please give me that dosing schedule. Doreen's neurologist's aim in prescribing Sinemet CR ONLY was to try to decrease the Sinemet-related dyskinesia(s)...which seems to have been accomplished on just 2 days of the
CR" only...BUT, her tremor has increased. I know...I know...it's very difficult to have it "both ways".

...and thank you so much to those of you who were kind enough to reply to my first post related to the Sinemet CR question...Vicky, TenaLouise, Paula and Evon. Paula...your thoughts, i.e., related to the Sinemet...less more frequently does seem more logical to me...and, in fact, Doreen was taking the "regular" Sinemet that way before her neurologist prescribed the Sinemet CR ONLY...and she seemed to be faring quite well on that regimen...as you said, too...more ability to control on this regimen.

We will see Doreen's neurologist this coming Friday, and once again, I will be "armed" with some information from the people here at this forum...thank you....

Therese