I don't know if this will help you, but I do take both Sinemet 25/100 and Sinemet CR 50/200. I take regular Sinemet 25/100 5 times per day along with other meds. I take 1 Sinemet CR 50/200 only once per day - the last dose before bed. The idea is that the CR stays in my system longer than regular Sinemet so I can stay asleep longer. It really does seem to have helped with my sleep problem although I still can't stay asleep through the entire night.

Approximate Schedule:

6:00am Sinemet 25/100, Mirapex 1mg, Comtan 200mg, Amantadine, and 2 tablets of an experiemental drug.

9:00am Sinemet 25/100, Mirapex, Comtan

12:00pm Sinemet 25/100, Mirapex, Comtan, Amantadine

3:30pm Sinemet 25/100, Mirapex, Comtan

7:00pm Sinemet 25/100, Mirapex, Comtan, Amantadine

10:30pm Sinemet CR 50/200, Mirapex, Comtan

3am Parcopa if needed due to sleeplessness