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03-25-2008, 03:52 PM | #1 | |||
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In Remembrance
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This is the clearest statement of something we all know but that most of the neuro research community seems oblivious of.
1: Rev Neurosci. 2007;18(3-4):209-22. Stress as a modulator of motor system function and pathology. Metz GA. Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada. gerlinde.metz@uleth.ca Stress is one of the most significant influences on behaviour and performance. The classical account is that stress mainly affects functions of the limbic system, such as learning, memory and emotion. Recent evidence, however, suggests that stress also modulates motor system function and influences the pathology of movement disorders. Most parts of the motor system show the presence of glucocorticoid receptors that render their circuits susceptible to the influence of stress hormones. Stress and glucocorticoids have been shown to modulate temporal and spatial aspects of motor performance. Skilled movements seem to be most prone to stress-induced disturbances, but locomotion and posture can also be affected. Stress can modulate movement through activation of the hypothalamic-pituitary-adrenal axis and via stress-associated emotional changes. The dopaminergic system seems to play a central role in mediating the effects of stress on motor function. This route might also account for the finding that stress influences the pathology of dopamine-related diseases of the motor system, such as Parkinson's disease. Clinical observations have indicated that stress might lead to the onset of Parkinsonian symptoms or accelerate their progression. Glucocorticoids are modulators of neuronal plasticity, thus determining the degree of structural and functional compensation of the damaged motor system. This may particularly affect slowly progressive neurodegenerative diseases, such as Parkinson's disease. That stress represents a significant modulator of motor system function in both the healthy and the damaged brain should be recognized when developing future therapies for neurodegenerative diseases. PMID: 18019607 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-25-2008, 04:11 PM | #2 | ||
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Junior Member
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He/She "Gets It". We "Get It" Now, somebody who can DO SOMETHING with "IT" has to "Get IT!!!" But, the info you presented is a start and the longest journey starts with the first step. So, I suppose this represents a "small, shaky shuffle" (like mine) forward.
It's just so frustrating that the simple message "stress impacts us negatively" would take so long to get the attention it deserves. Thanks for the info. Keith |
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03-25-2008, 05:47 PM | #3 | |||
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In Remembrance
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That is, what things that you would have brushed off in times gone by now pose a problem?
For me, it verges on the ridiculous at times. Trying to reach a ringing telephone in time. Waiting in a line knowing others are behind me. A need to carry on a conversation when not quite "on". A disruption of my plans for the day. Any of these can screw me up for the whole day. Sound familiar?
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-25-2008, 06:22 PM | #4 | |||
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Senior Member
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Quote:
Peg |
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03-25-2008, 07:22 PM | #5 | ||
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In Remembrance
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Teachers are right up there Peg, and we never do learn to settle down do we?
We have to control this and I find that I have to walk away from stress...break away from it, but that isn't always possible. We do have to attempt to manage it somehow tho, as a primary symptom and possibly cause, and eliminate unnecessary stress if possible to survive longer. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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03-25-2008, 09:30 PM | #6 | |||
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Member
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Maybe the placebo effect works in the reverse. I want so much to harness the placebo effect without taking a placebo in a trial.
What steps can we take to imagine we're taking a miracle drug, so we get the same effect as sham surgery. I really don't know how to go about doing that. Does pessimism get in my way? I don't know. I keep putting off taking Zandopa (mucuna pruriens) because I can never afford to be nauseous. I'd like to use it with a belief that it will really work great for me, even if it's just a placebo effect. |
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01-26-2011, 02:24 PM | #7 | |||
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In Remembrance
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bump bump bump
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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