I've had PD for 10years,and on one form of sinemet or another for most of that time.In my individual case I have found the following:!.Taking meds on an empty stomach increases effectiveness dramatically.I wait at least 45 mins. after dosing before eating anything.2.Eating any form of protein eggs steak etc before or shortly after negates any effect I get from sinemet.3. Liberal amts of water used while dosing seems to speed on time.4.Any caffine or alcohol tkes me immediately to off time.5.Some days doesn't matter what I do can't get any decent on time for meds.Could be i slipped and had a snack when I should not have or the waitress messed up and served me caffinated instead of decafinated.In closing i would say in my case diet plays a greater role then amt of med taken .This is strictly meant in my case all are different.Sure is one difficult disease to deal with.Wishing all the best.