I broke a tooth last week, which got infected, and within 2 days had the most serious relapse I have ever suffered. I had to be helped to dress, helped into bed etc. I literally could not move when unmedicated. My meds did not work, until I increased them to unheard of levels, and visited the dentist. Trouble was I was now writhing around with dyskinesia, and he put a temporary filling in, with disinfectant, and then abhorted the appointment.
In the meantime, my neuro advised me to have it extracted, rather than try to save it, and get totally clear of infection. That is arranged for 2 days time. The inflamed gum has receeded to some extent, presumably due to the disinfectant in the filling, and I am improving.
I did not realise an infection could cause such a trough in symptoms, so thought it worth posting, in case others are also unaware. I did a search and found plenty of evidence for the link between infection and a relapse in symptoms. See

http://goliath.ecnext.com/coms2/summ...99-6764595_ITM
Infections, drug changes can bring Parkinson's to the ED.(emergency department)

http://www.foxnews.com/story/0,2933,146096,00.html
There are a lot of different processes that can make Parkinson's worse, and infections are one of them."

Anyone else had a similar experience? Seems we have got to beware
gum infections, skin infections, measles, urine infections, herpes, gut infections etc.
Ron

Hi Ron,

Back in late January/early February, the flu bug went through my house. I avoided it for the longest time, but then it hit me pretty hard. The same thing happened to me. I was so miserable I could barely get around. Once the fever broke, everything came back to normal over the next few days.

I've noticed that in general when I am stresed or over tired that the symptoms are worse. I am more tremulous internally, I am stiff, and more crampy.

Thank you for the interesting links.

John

There are several factors to consider. First, infected teeth are legendary causes of trouble and even death. (My wife is a former dental hygienist and I have absorbed a lot over the years.) This is particularly true if the tooth is an upper due to the honey-combed bone allowing possible access directly to the brain. These can be asymptomatic if an outlet is found since the pressure does not build up and tip you off yet toxins are going into your system for years.

The toxins produced by growing bacteria are called exotoxins and can be deadly. The immune system attacks the bacteria and the toxins decrease. But there is another kind of toxin called endotoxins that are released only as the bacteria dies. A sort of "poison pill" defense. When these toxinsmake it into the brain they trigger a special branch of the immune system called the microglia. These mop up the mess in a normal person and all is well.

However, in a PWP it doesn't end there. In fact, a single exposure to endotoxin sets off a melee that continues for months and neurons are killed in the crossfire. Furthermore, all that chemical soup has neuroactive powers and screws up the brain chemistry, which is probably what Ron encountered. Hopefully, he is backon the curcumin because it is one of the things that stops the process.

For more mind-numbing detail:
http://www.parkinsonsonline.org/4.02...he_CNS.mm.html

infections, set to disrupt our delicately poised sinemet induced bodies into an unwelcome trauma that we would rather not have. Experience suggests the only way forward is to ride it out..... the alternative.........there is none. And if we are in reasonable shape, and have solid support most of us will do the hard yards and bounce back. All the best with that tooth Ron....the rest of us.......stay healthy