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Old 12-20-2008, 09:14 AM #1
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Default Method to test dysfunctional BBB

I don't have the medical knoweledge to know whether this guy is Kosher or not, but he offers a test and solution to a leaky BBB!!!
The paragraph that made me sit up is
"The test is to take 1000mg of GABA and see if you feel any enhanced state of relaxation. If you do then this substance has crossed the BBB and you have a “leaky brain!” Bad news. You need to fix that pronto! Oral GABA should not induce relaxation. If it does I can help you with this."
Is this a simple test to show Parkies have a defective BBB, and what does his solution do for PD symptoms??

Anyone live near to San Diego??
Ron

See
http://laurelacupuncturesd.blogspot....ow-part-2.html
Much like the way that it sounds, leaky brain syndrome is a situation where the blood-brain-barrier (BBB) has become compromised and substances that are not meant to cross this barrier are able to pass either in or out unchecked. This barrier was discovered in the 19th century by the bacteriologist Ehrlich. He found that when he injected animals with staining chemicals every part of the animal took the stain but the brain. And subsequently when he injected the stain directly into the central nervous system nothing outside the brain took the color. The scientist therefore demonstrated that there was something that was stopping the transport of chemicals into and out of the brain. And this was for a good reason. The brain is of course a highly important organ for every function in our body and needs a high level of protection from harmful substances. When this barrier system becomes compromised the brain becomes susceptible to damage by invading substances and pathogens. The bottom line is you want a nice and tight, non-leaky blood-brain-barrier!

There is now current research that demonstrates to us the things that can both help and hurt this barrier system. Just several of the ones that harm the barrier should sound familiar to many of you. I see them in my practice all of the time. Increased oxidation due to free radical exposure, elevated Homocysteine (also a heart disease risk), stress of any kind (physical, mental/emotional, chemical), alcohol, and elevated blood sugar all work to destroy the BBB. If there is any one thing that I see the most of it is poor blood sugar regulation. Controlling all of these things as well as taking in Alpha-Lipoic Acid, antioxidants and simply using your brain all work to help maintain and rebuild the BBB.

This all becomes very important when considering the treatment and better yet, the prevention of many of the modern medical problems facing our society today. Loss of BBB integrity has been linked to several disease processes including meningitis, multiple sclerosis, Alzheimer’s Disease, and Parkinson’s Disease. These studies can be found in highly respected medical journals like the Journal of Alzheimer’s Disease, Neurotoxicology, Journal of Leukocyte Biology, Brain Research and more.

If you are interested in seeing if you might have a leaky brain condition there is a simple field test that you can perform on yourself. At the health food store you can purchase a supplement called GABA. GABA is a neurotransmitter found in the brain which elicits a relaxed state. People who are low in GABA tend to have anxiety type disorders. This substance should not be able to cross the BBB. (Which makes you wonder why it is being sold at all!) The test is to take 1000mg of GABA and see if you feel any enhanced state of relaxation. If you do then this substance has crossed the BBB and you have a “leaky brain!” Bad news. You need to fix that pronto! Oral GABA should not induce relaxation. If it does I can help you with this.

Believe me, there are a lot of things out there that if they get into your brain can lead to serious damage. Our brains are not supposed to have foreign substances in contact with it so when that happens the response is severe. Quite literally our immune system can go on a killing spree in a last ditch effort to save our brain from damage and in doing so will wipe out everything in its path including brain tissue! Counter productive, yes, but it is what we have, and it is good to know about.

Don’t let this happen to you. There are simple steps that you can take to protect yourself from a leaky brain. I am happy to be your guide in proper brain health. This is seriously one area of medicine both mainstream and alternative alike that is consistently overlooked time and time again. And in the meantime neurological disorders are continuously on the rise. Call to day for a consultation and request a free Brain Health Questioner.
Posted by Jim Chialtas, L.Ac. at 1:06 PM
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Old 12-20-2008, 11:37 AM #2
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Default some confusion - so what else is new

A quick and dirty Medline search (GABA + BBB) turned up little plain talk. The best I came up with is below:

1: Brain Res Bull. 2002 Jan 15;57(2):231-6.

Evidence that nitric oxide production increases gamma-amino butyric acid
permeability of blood-brain barrier.

Shyamaladevi N, Jayakumar AR, Sujatha R, Paul V, Subramanian EH.

Dept of Biophysics and Crystallography, University of Madras, Chennai, India.

Blood-brain barrier permeability (BBB) to the inhibitory neurotransmitter
gamma-amino butyric acid (GABA) was studied in rats following intraperitoneal
(i.p) injections of GABA alone and in combination with L-Arginine (L-Arg).
Administration of GABA (600 mg/kg body weight [b. wt.]) alone increased brain
GABA concentration (33%, p < 0.01), when compared to untreated rats and
administration of L-Arg (2000 mg/kg b. wt.) alone also increased GABA
concentration (65%, p < 0.01) in the brain. Moreover, GABA + L-Arg treated brains
showed a fourfold increase in GABA level (383.3%, p < 0.01) when compared to
controls. Dose-dependent increase in nitric oxide production was observed 10 min
after i.p injections of L-Arg (400, 800, 1000, and 2000 mg/kg b. wt.) and a peak
nitric oxide (NO) production was observed at the dose level of 2000 mg/kg b. wt.
On the other hand, administration of GABA failed to increase NO production in the
brain. Rats pretreated (10 min) with a nonspecific nitric oxide synthase (NOS)
inhibitor N(omega)-nitro-L-Arginine methyl ester (L-NAME, 50 mg/kg b. wt.)
completely blocked the production of NO induced by L-Arg. In addition, L-NAME
attenuated GABA entry into the brain after the administration of GABA alone or in
combination with L-Arg. We conclude that high NO concentrations in the brain
following L-Arg administration may increase the permeability of BBB to peripheral
GABA.


PMID: 11849830 [PubMed - indexed for MEDLINE]
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Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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Old 12-21-2008, 12:36 PM #3
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Default BBB permeability

Anyone here with MJFF 's scientific board's ear(s) able to inquire/suggest/cajole the group into looking at this issue????madelyn
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Old 12-21-2008, 04:36 PM #4
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Default what else doesn't cross the BBB?

Sorry to sound like a broken record, but I have sent threads on this to MJFF and received responses, which referred me to studies - I posted the response but it's been awhile.

Ron, my flags go up on this man's claims. I don't mean to sound discouraging, and you know I wish he could do as he claims as much as you do ...it just sounds too easy.

I would like to know just how much stuff we are purchasing for the brain that is not crossing the blood brain barrier.......that's outrageous and a study in itself!

paula
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Old 12-22-2008, 03:29 AM #5
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Default

Ron,
Just read this thread. A quick note to let you know that I live in san diego and i know Jim. My dentist recommended him and went to his cclinic for acupuncture about three years ago. it did give me relief from muscle ache and in fact I have been thinkining of going back to him for aacupuncture/ Jim is a genuine guy, caring and committed to patient health. I donot know where he got GABA info, I can find out from him.

girija








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Old 12-22-2008, 11:25 AM #6
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Default Dysfunctional BBB

Girija,
Many thanks, do you mean Jim's treatment for repairing a dysfunctional BBB is based on accupuncture?? I will be very interested in what you find out.

Paula,
Yes, I was suspicious of his claims also, but I trust Girija's judgement and will be interested to follow it up.
Ron
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Old 12-22-2008, 07:15 PM #7
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Default Acupuncture and BBB?????

Ron and Paula,
I agree his brochure oversimplifies neurological disorders to leaky BBB which might be one of the many components. But this guy has BS or MS in molecular biology and biochem from one of the UC schools. He developed interest in oriental medicine and was intrigued by ancient methods of treatment. After graduating from school, he pursued acupuncture. I donot know for sure if he treats for leaky BBB by acupuncture. I will talk to him and direct him to this site and he can post and talk to you all. Is it OK to do that????? or is it considered advertising? Moderators, please advise.

thanks
Girija



Quote:
Originally Posted by Ronhutton View Post
Girija,
Many thanks, do you mean Jim's treatment for repairing a dysfunctional BBB is based on accupuncture?? I will be very interested in what you find out.

Paula,
Yes, I was suspicious of his claims also, but I trust Girija's judgement and will be interested to follow it up.
Ron
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Old 01-04-2009, 09:21 AM #8
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Default BBB repair?

Girija,
Did you get any information from Jim the accupuncturist in San Diego? It should surely be OK for him to join our debates here, did the moderators reply?
Best wishes for the New Year
Ron
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Old 01-04-2009, 07:40 PM #9
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Default BBB info

Ron,
Post-holiday life starts from tomorrow and Jim should be available this week. I will get in touch with him and hope to have him join us in this ongoing discussion. I am assuming its ok to invite him here since I didnt hear other wise from the moderators.

Girija
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Old 01-05-2009, 01:35 PM #10
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Exclamation

Hi,

I just wanted to be sure y'all are aware that Mods Do NOT read every post. There is no way we could. A member alerted me to this thread.

Anyone can join. We don't allow them to solicate member or advertise.

Discussion by everyone is great. We have many professionals who post.

Any questions, send me a PM.

Curious
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"Thanks for this!" says:
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