Parkinson's Disease Tulip


advertisement
Reply
 
Thread Tools Display Modes
Old 12-26-2008, 11:12 AM #21
lurkingforacure lurkingforacure is offline
Senior Member
 
Join Date: Feb 2008
Posts: 1,485
15 yr Member
lurkingforacure lurkingforacure is offline
Senior Member
 
Join Date: Feb 2008
Posts: 1,485
15 yr Member
Default what about being contagious?

Everything I have read says that all viruses are contagious, otherwise they would die out (have to have a host, apparently). The methods of spreading from one host to another vary, such as the common cold (simply breathing in the air) versus AIDS (actual physical involvement).

So then the question becomes, if a virus or viruses are involved in PD, why haven't the spouses and children of the family member with PD fallen ill also? I tried to search this out and everything I found said PD is NOT contagious and I was unable to find more than two isolated and non-related cases where both spouses had PD (or a PD and Lewey Body). And MJF had children AFTER dx, and his wife and beautiful family look the picture of perfect health. This makes me wonder if a virus might not be involved after all.

Maybe the virus sets the stage but isn't the actual catalyst. Or maybe the non-PD spouse has superior immunity to the virus and just doesn't get it despite contact (but then I think how impossible that really is-all nonPD spouses can't be THAT healthy!). hmmmmm...
lurkingforacure is offline   Reply With QuoteReply With Quote

advertisement
Old 12-26-2008, 11:20 AM #22
reverett123's Avatar
reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default Here is a place to start

This link is to an NIH online text "Polymicrobial Diseases" and a discussion of combined virus/bacteria diseases. It is actually readable-

http://www.ncbi.nlm.nih.gov/bookshel...d&part=IV.bxml

and this one takes you to a site about the Marshall Protocol which is very similar to what you are looking for.
__________________
Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
reverett123 is offline   Reply With QuoteReply With Quote
Old 12-26-2008, 02:01 PM #23
Ronhutton's Avatar
Ronhutton Ronhutton is offline
In Remembrance
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Ronhutton Ronhutton is offline
In Remembrance
Ronhutton's Avatar
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Default Puzzle

Hi Lurkingforacure,
You are doing the right thing asking yourself such questions. It is a surefire way of making progress in research.
I think combined with "What if?" you can make progress. What if having a virus like the Herpes virus, or an infection like Helicobacter Pilori, needed to be combined with a defective BBB? There is no rule which says you can't have two things wrong with you at the same time, and the odds can't be too high.
The Herpes virus is widespread, yet many people have it who don't have PD. The same thing goes for many infections. However, if you are unlucky enough to have maybe a genetic fault rendering you to have a dysfunctional BBB, you would be at the mercy of every virus and bacteria lurking in your system.
See the reference in my last post,

http://www.sciencedaily.com/releases...0902221735.htm
The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis);

Such infections are shown to lead to brain inflammmation, due to the leaky BBB. If you add "who have a defective BBB" after "some individuals, it makes a lot more sense. In a healthy person, (with a functioning BBB) they can be infected with the odd virus or bacteria, and the toxins circulate harmlessly in the blood. When you suffer from a leaky BBB, they get into the brain.
If you read my past posts, you will see everything which tightens the permeability of the BBB (like curcumin), improves symptoms, everything which widens it, like stress, causes an accentuatuation of PD. It all becomes a lot clearer, yet it is not a far fetched explanation.
Ron
__________________
Diagnosed Nov 1991.
Born 1936
Ronhutton is offline   Reply With QuoteReply With Quote
Old 12-26-2008, 05:06 PM #24
Lara Lara is offline
Legendary
 
Join Date: Sep 2006
Posts: 10,984
15 yr Member
Lara Lara is offline
Legendary
 
Join Date: Sep 2006
Posts: 10,984
15 yr Member
Default

Quote:
Originally Posted by lurkingforacure View Post
Maybe the virus sets the stage but isn't the actual catalyst. Or maybe the non-PD spouse has superior immunity to the virus and just doesn't get it despite contact (but then I think how impossible that really is-all nonPD spouses can't be THAT healthy!). hmmmmm...
Or maybe there is a genetic predisposition in the one (PD) person that is not in the other.
Lara is offline   Reply With QuoteReply With Quote
Old 01-02-2009, 05:30 PM #25
girija girija is offline
Member
 
Join Date: Nov 2006
Location: southern tip of west coast
Posts: 582
15 yr Member
girija girija is offline
Member
 
Join Date: Nov 2006
Location: southern tip of west coast
Posts: 582
15 yr Member
Default virus-autoimmunity and PD

This recent thread adds a bit more to PD and autoimmunity discussion. Bumping it up.

Girija
girija is offline   Reply With QuoteReply With Quote
Old 01-03-2009, 03:32 AM #26
Ronhutton's Avatar
Ronhutton Ronhutton is offline
In Remembrance
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Ronhutton Ronhutton is offline
In Remembrance
Ronhutton's Avatar
 
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
15 yr Member
Default Why not spouses?

Lara,
I think the simple reason why spouses do not get PD as well, is although they may probably get infected with the same virus or infection, they have a good functioning BBB which keeps out the toxins from the brain.
Those of us with PD, have it because we have lost the protection of our BBB. Our BBB is dysfunctional, and allows substances into the brain that it should keep out. It is possible a leaky BBB is genetic.
I remember William Frey in one of his publications years ago, said "If a leaky BBB allows bad things into the brain, it could be used to allow good things in too". He then did the research on using it as a method of drug delivery via the nasal route.
Ron
__________________
Diagnosed Nov 1991.
Born 1936
Ronhutton is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Lara (01-03-2009)
Old 01-03-2009, 08:35 AM #27
lou_lou's Avatar
lou_lou lou_lou is offline
In Remembrance
 
Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
15 yr Member
lou_lou lou_lou is offline
In Remembrance
lou_lou's Avatar
 
Join Date: Sep 2006
Location: about 45 minutes to anywhere!
Posts: 3,086
15 yr Member
Lightbulb Dr. Robert O Becker - "Cross Currents"

Dr. Robert O. Becker -who was born in 1923 & passed away in 2008
was a great mind - he had many theories about electromagnetic energy fields.
in his book Cross Currents - Chapter 11
http://omega.twoday.net/20060718/

Dr. Becker refers to several neurodegenerative illnesses as -
the "New Plagues" - and he specifically calls "Parkinson's Disease"
one of these plagues...
do the research...
http://www.emfbioshield.com/books/crosscurrents.html
we need to think for ourselves.
__________________
with much love,
lou_lou


.


.
by
.
, on Flickr
pd documentary - part 2 and 3

.


.


Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these.

Last edited by lou_lou; 01-03-2009 at 09:18 AM.
lou_lou is offline   Reply With QuoteReply With Quote
Old 01-09-2009, 08:00 AM #28
Lara Lara is offline
Legendary
 
Join Date: Sep 2006
Posts: 10,984
15 yr Member
Lara Lara is offline
Legendary
 
Join Date: Sep 2006
Posts: 10,984
15 yr Member
Default sorry if this is information overload, but...

I'm trying to not overstep the bounds of copyright here. It's difficult trying to cut down a very long article.

From Medscape Nurses.
http://www.medscape.com/viewarticle/574944_1
From Laboratory Medicine
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases

Posted 06/23/2008
Author Information
Garth L. Nicolson, PhD, Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA

<snipped article>

Quote:
Often, patients with neurodegenerative or neurobehavioral diseases have chronic, neuropathic infections that could be important in disease inception, disease progression, or increasing the types or severities of signs and symptoms.
Quote:
Although controversial, the majority of patients with various neurodegenerative or neurobehavioral conditions, such as amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and autistic spectrum disorders, show evidence of central nervous system or systemic bacterial and viral infections.
Quote:
Although chronic infections were not found in some studies, and the specific role of chronic infections in neurological disease pathogenesis has not been determined or is inconclusive, the data suggest that chronic bacterial or viral infections could be common features of progressive neurodegenerative and neurobehavioral diseases.
Quote:
Inflammation and autoimmune responses have also been attributed to other chronic infections found in PD.[115-117] Indeed, experimental models of PD have been developed using neurological, viral, or bacterial infections to initiate the pathogenic process.[118,119]
Quote:
In humans, spirochetes have been found in Lewy bodies of PD patients.[29] Other infections, such as viral encephalitis,[120] AIDS-associated opportunistic infections of the basal ganglia,[121] coronavirus,[122] and other infections,[63,123,124] have been found in PD and could be important in stimulating inflammation and autoimmune responses.
Quote:
Richy and M้graud[125] have stressed, however, that more rigorous investigations will be required to establish whether a causal link exists between infections and PD.
references...

29 Halperin JJ, Kaplan GP, Brazinsky S, et al. Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease. Arch Neurol. 1990;47:586–594.
63 Nicolson GL. Systemic intracellular bacterial infections (Mycoplasma, Chlamydia, Borrelia species) in neurodegenerative (Alzheimers, MS, ALS) and behavioral diseases (Autistic Spectrum Disorders). Townsend Lett. 2008;295:74–84.
115 Barker RA, Cahn AP. Parkinson's disease: an autoimmune process. Int J Neurosci. 1988;43:1–7.
116 Wersinger C, Sidhu A. An inflammatory pathomechanism for Parkinson's disease. Curr Med Chem. 2006;13:591–602.
117 Arai H, Furuya T, Mizuno Y, et al. Inflammation and infection in Parkinson's disease. Histol Histopathol. 2006;21:673–678.
118 Ogata A, Tashiro K, Nukuzuma S, et al. A rat model of Parkinson's disease induced by Japanese encephalitis virus. J Neurovirol. 1997;3:141–147.
119 Beaman BL, Canfield D, Anderson J, et al. Site-specific invasion of the basal ganglia by Nocaardia asteriodes GUH-2. Med Microbiol Immunol. 2000;188:161–168
120 Ickenstein GW, Klotz JM, Langohr HD. Virus encepthalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism. Fortschr Neurol Psychiatr. 1999;67:476–481.
121 Maggi P, de Mari M, Moramarco A, et al. Parkinsonism in a patient with AIDS and cerebral opportunistic granulomatous lesions. Neurol Sci. 2000;21:173–176.
122 Fazzini E, Fleming J, Fahn S. Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease. Mov Disord. 1992;7:153–158.
123 Alasia DD, Asekomeh GA, Unachuku CN. Parkinsonism induced by sepsis: A case report. Niger J Med. 2006;15:333–336.
124 Fiszer U, Tomik B, Grzeslowski P, et al. The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non-neurological diseases. Acta Neurol Scand. 2004;110:113–117.
125 Richy F, M้graud F. Helicobacter pylori infection as a cause of extra-digestive diseases: Myth or reality? Gastroenterol Clin Biol. 2003;27:459–466.
Lara is offline   Reply With QuoteReply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Hit with another virus MJA - TOS Computers and Technology 7 12-20-2008 06:19 PM
EMZ virus bizi Survivors of Suicide 3 05-14-2008 09:09 PM
not sure about this virus better to be warned weegot5kiz Computers and Technology 2 04-27-2008 01:43 PM
new net virus -CNN lou_lou Parkinson's Disease 0 08-13-2007 02:36 PM


All times are GMT -5. The time now is 03:32 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.