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12-26-2008, 11:12 AM | #21 | ||
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Everything I have read says that all viruses are contagious, otherwise they would die out (have to have a host, apparently). The methods of spreading from one host to another vary, such as the common cold (simply breathing in the air) versus AIDS (actual physical involvement).
So then the question becomes, if a virus or viruses are involved in PD, why haven't the spouses and children of the family member with PD fallen ill also? I tried to search this out and everything I found said PD is NOT contagious and I was unable to find more than two isolated and non-related cases where both spouses had PD (or a PD and Lewey Body). And MJF had children AFTER dx, and his wife and beautiful family look the picture of perfect health. This makes me wonder if a virus might not be involved after all. Maybe the virus sets the stage but isn't the actual catalyst. Or maybe the non-PD spouse has superior immunity to the virus and just doesn't get it despite contact (but then I think how impossible that really is-all nonPD spouses can't be THAT healthy!). hmmmmm... |
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12-26-2008, 11:20 AM | #22 | |||
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In Remembrance
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This link is to an NIH online text "Polymicrobial Diseases" and a discussion of combined virus/bacteria diseases. It is actually readable-
http://www.ncbi.nlm.nih.gov/bookshel...d&part=IV.bxml and this one takes you to a site about the Marshall Protocol which is very similar to what you are looking for.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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12-26-2008, 02:01 PM | #23 | |||
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In Remembrance
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Hi Lurkingforacure,
You are doing the right thing asking yourself such questions. It is a surefire way of making progress in research. I think combined with "What if?" you can make progress. What if having a virus like the Herpes virus, or an infection like Helicobacter Pilori, needed to be combined with a defective BBB? There is no rule which says you can't have two things wrong with you at the same time, and the odds can't be too high. The Herpes virus is widespread, yet many people have it who don't have PD. The same thing goes for many infections. However, if you are unlucky enough to have maybe a genetic fault rendering you to have a dysfunctional BBB, you would be at the mercy of every virus and bacteria lurking in your system. See the reference in my last post, http://www.sciencedaily.com/releases...0902221735.htm The most common symptom of infection is a cold sore, but in some individuals the virus can also cause life-threatening inflammation of the brain (encephalitis); Such infections are shown to lead to brain inflammmation, due to the leaky BBB. If you add "who have a defective BBB" after "some individuals, it makes a lot more sense. In a healthy person, (with a functioning BBB) they can be infected with the odd virus or bacteria, and the toxins circulate harmlessly in the blood. When you suffer from a leaky BBB, they get into the brain. If you read my past posts, you will see everything which tightens the permeability of the BBB (like curcumin), improves symptoms, everything which widens it, like stress, causes an accentuatuation of PD. It all becomes a lot clearer, yet it is not a far fetched explanation. Ron
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Diagnosed Nov 1991. Born 1936 |
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12-26-2008, 05:06 PM | #24 | |||
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Legendary
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01-02-2009, 05:30 PM | #25 | ||
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Member
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This recent thread adds a bit more to PD and autoimmunity discussion. Bumping it up.
Girija |
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01-03-2009, 03:32 AM | #26 | |||
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In Remembrance
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Lara,
I think the simple reason why spouses do not get PD as well, is although they may probably get infected with the same virus or infection, they have a good functioning BBB which keeps out the toxins from the brain. Those of us with PD, have it because we have lost the protection of our BBB. Our BBB is dysfunctional, and allows substances into the brain that it should keep out. It is possible a leaky BBB is genetic. I remember William Frey in one of his publications years ago, said "If a leaky BBB allows bad things into the brain, it could be used to allow good things in too". He then did the research on using it as a method of drug delivery via the nasal route. Ron
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Diagnosed Nov 1991. Born 1936 |
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"Thanks for this!" says: | Lara (01-03-2009) |
01-03-2009, 08:35 AM | #27 | |||
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In Remembrance
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Dr. Robert O. Becker -who was born in 1923 & passed away in 2008
was a great mind - he had many theories about electromagnetic energy fields. in his book Cross Currents - Chapter 11 http://omega.twoday.net/20060718/ Dr. Becker refers to several neurodegenerative illnesses as - the "New Plagues" - and he specifically calls "Parkinson's Disease" one of these plagues... do the research... http://www.emfbioshield.com/books/crosscurrents.html we need to think for ourselves.
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with much love, lou_lou . . by . , on Flickr pd documentary - part 2 and 3 . . Resolve to be tender with the young, compassionate with the aged, sympathetic with the striving, and tolerant with the weak and the wrong. Sometime in your life you will have been all of these. Last edited by lou_lou; 01-03-2009 at 09:18 AM. |
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01-09-2009, 08:00 AM | #28 | ||||||
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Legendary
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I'm trying to not overstep the bounds of copyright here. It's difficult trying to cut down a very long article.
From Medscape Nurses. http://www.medscape.com/viewarticle/574944_1 From Laboratory Medicine Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases Posted 06/23/2008 Author Information Garth L. Nicolson, PhD, Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA <snipped article> Quote:
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29 Halperin JJ, Kaplan GP, Brazinsky S, et al. Immunologic reactivity against Borrelia burgdorferi in patients with motor neuron disease. Arch Neurol. 1990;47:586594. 63 Nicolson GL. Systemic intracellular bacterial infections (Mycoplasma, Chlamydia, Borrelia species) in neurodegenerative (Alzheimers, MS, ALS) and behavioral diseases (Autistic Spectrum Disorders). Townsend Lett. 2008;295:7484. 115 Barker RA, Cahn AP. Parkinson's disease: an autoimmune process. Int J Neurosci. 1988;43:17. 116 Wersinger C, Sidhu A. An inflammatory pathomechanism for Parkinson's disease. Curr Med Chem. 2006;13:591602. 117 Arai H, Furuya T, Mizuno Y, et al. Inflammation and infection in Parkinson's disease. Histol Histopathol. 2006;21:673678. 118 Ogata A, Tashiro K, Nukuzuma S, et al. A rat model of Parkinson's disease induced by Japanese encephalitis virus. J Neurovirol. 1997;3:141147. 119 Beaman BL, Canfield D, Anderson J, et al. Site-specific invasion of the basal ganglia by Nocaardia asteriodes GUH-2. Med Microbiol Immunol. 2000;188:161168 120 Ickenstein GW, Klotz JM, Langohr HD. Virus encepthalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism. Fortschr Neurol Psychiatr. 1999;67:476481. 121 Maggi P, de Mari M, Moramarco A, et al. Parkinsonism in a patient with AIDS and cerebral opportunistic granulomatous lesions. Neurol Sci. 2000;21:173176. 122 Fazzini E, Fleming J, Fahn S. Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease. Mov Disord. 1992;7:153158. 123 Alasia DD, Asekomeh GA, Unachuku CN. Parkinsonism induced by sepsis: A case report. Niger J Med. 2006;15:333336. 124 Fiszer U, Tomik B, Grzeslowski P, et al. The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non-neurological diseases. Acta Neurol Scand. 2004;110:113117. 125 Richy F, M้graud F. Helicobacter pylori infection as a cause of extra-digestive diseases: Myth or reality? Gastroenterol Clin Biol. 2003;27:459466. |
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