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03-08-2009, 07:46 AM | #1 | |||
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In Remembrance
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Melatonin is produced by the pineal gland. It is probably more a question of what is the pineal gland since melatonin is its messenger. The PG is a central part of the time-keeping system of our bodies and seems to be regulated by light by way of signals from the retina. When the retina sees light the PG stops making melatonin and resumes in the dark.
But, like much of the endocrine system, we just don't know. Until relatively recently it was considered to be one of those "vestigal organs" that we seemed to have several of.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-08-2009, 11:59 AM | #2 | ||
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Senior Member
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So where does that leave us heavy computer users who spend hours of our night time in front of a screen?
Quote:
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03-08-2009, 01:32 PM | #3 | ||
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Woo Woo things to think about........http://www.crystalinks.com/thirdeyepineal.html
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03-08-2009, 04:43 PM | #4 | ||
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In Remembrance
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lindy, you asked where does that leave heavy nighttime computer users?
perhaps not as bad as we could be? Or, conversely,since melatonin is also recommended to help with sleep, perhaps we are harming ourselves. i'm guessing it's one or the other... ibby - that's an interesting page about the pineal gland. And just to top it off, remember it was Edgar Cayce who said PD started in the glands. i could wonder out loud/speculate about a lot of things here...about light and following it...especially regarding a gland that has mythical background ...even being called the soul. But i can't, so I won't. maybe someday we can include other means of healing in our discussions and gain knowledge and experience about the signs and capabilities that are never used or realized. This pineal gland discussion led us to a page that was completely unexpected yet fits in to my life [in that its' history is tied to a place outside the real world] as I seek more of a spiritual realm. And this part of us [ comtemplating our own mortality] is completely normal - many of us are in the age "zone". I think it's fascinating. Rick, you are a busy guy - see what you have produced today? i'm picturing a scene from A River Runs Through It...of course it includes Brad Pitt and a fish. I'd rather do that than meditate...no focus. lol Thanks ibby - more connections to think about. It's gorgeous today in Florida...in the 80s. I need to go out and turn off my melatonin. paula
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paula "Time is not neutral for those who have pd or for those who will get it." |
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"Thanks for this!" says: | lou_lou (03-08-2009) |
03-08-2009, 07:09 PM | #5 | |||
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In Remembrance
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1: Cell Mol Neurobiol. 2001 Dec;21(6):605-16.
Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting. Zisapel N. Department of Neurobiochemistry, Tel Aviv University, Israel. navazis@post.tau.ac.il To review the interaction between melatonin and the dopaminergic system in the hypothalamus and striatum and its potential clinical use in dopamine-related disorders in the central nervous system. Medline-based search on melatonin-dopamine interactions in mammals. Melatonin. the hormone produced by the pineal gland at night. influences circadian and seasonal rhythms, most notably the sleep-wake cycle and seasonal reproduction. The neurochemical basis of these activities is not understood yet. Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina). Antidopaminergic activities of melatonin have been demonstrated in the striatum. Dopaminergic transmission has a pivotal role in circadian entrainment of the fetus, in coordination of body movement and reproduction. Recent findings indicate that melatonin may modulate dopaminergic pathways involved in movement disorders in humans. In Parkinson patients melatonin may, on the one hand, exacerbate symptoms (because of its putative interference with dopamine release) and, on the other, protect against neurodegeneration (by virtue of its antioxidant properties and its effects on mitochondrial activity). Melatonin appears to be effective in the treatment of tardive dyskinesia. a severe movement disorder associated with long-term blockade of the postsynaptic dopamine D2 receptor by antipsychotic drugs in schizophrenic patients. The interaction of melatonin with the dopaminergic system may play a significant role in the nonphotic and photic entrainment of the biological clock as well as in the fine-tuning of motor coordination in the striatum. These interactions and the antioxidant nature of melatonin may be beneficial in the treatment of dopamine-related disorders. PMID: 12043836 [PubMed - indexed for MEDLINE]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-08-2009, 08:13 PM | #6 | |||
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Member
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Please excuse my total ignorance, but I'm enticed by you "Current Blend". Is this just an all over feel good blend or have you specifically picked each one for Parkinsons? Thanks, I find your post very interesting!
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03-09-2009, 04:41 AM | #7 | |||
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In Remembrance
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These are the things that I have tried and/or researched enough to attempt to take regularly. It is up-to-date at the moment but slips from time to time.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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03-09-2009, 04:49 AM | #8 | |||
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In Remembrance
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I just realized that I didn't answer your question. They are all PD oriented. The ALA-ALC-Carnosine combination boosts mitochondrial function and fights glycation. The B-vitamins pop up in the nervous system every time you turn around. Ginseng and gingko help with stress damage and the former is a top adaptogen. Turmeric does so many things that I won't try to list them all. Fish oil is anti-inflammatory and provides one of the primary building blocks of brain tissue.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000. Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well. |
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"Thanks for this!" says: | gardengrl (03-10-2009) |
03-10-2009, 05:52 PM | #9 | |||
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Member
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Thank you! You have been most helpful...
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