[pd_edu]

I heard this on the news this today. so I checked it out on google news . There are 9 stories about it so far, some refer to pd , others to alzheimer's . Thought I must share this with this forum as it adds to the existing evidence about inflammation being one serious culprit, and , who knows, maybe its a significant find.

Molecule offers hope for Parkinson's treatment
ABC Online - ‎9 hours ago‎
Australian scientists have identified a molecule which controls inflammation in the brain, offering hope of a future treatment for conditions such as ...
Parkinson's. A study from Sydney's Garvan Institute has found that nerve cells in the brain produce an anti-inflammatory molecule that triggers the brain to repair itself.

Lead researcher Dr Bryce Vissel says they found that giving over the counter anti-inflammatory drugs to mice could allow brain regeneration.

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edit *copyright article*

[pacem]

Benadryl, 25 mg. nightly, generic or brand, has made a noticable and positive improvement in symptoms for me. Less headaches, more energy, less insomnia, less dyskinesia, and slightly less tremor. About 6 weeks into treatment so far.

[Ibken]

Originally Posted by pacem

Benadryl, 25 mg. nightly, generic or brand, has made a noticable and positive improvement in symptoms for me. Less headaches, more energy, less insomnia, less dyskinesia, and slightly less tremor. About 6 weeks into treatment so far.

Are you self-medicating - or following an Md's RX? Any 'side effects' so far?
What does Benadryl do - act as an anti-infllammatory?

ibby

[Ibken]

Originally Posted by pd_edu

I heard this on the news this today. so I checked it out on google news . There are 9 stories about it so far, some refer to pd , others to alzheimer's . Thought I must share this with this forum as it adds to the existing evidence about inflammation being one serious culprit, and , who knows, maybe its a significant find.

Molecule offers hope for Parkinson's treatment
ABC Online - ‎9 hours ago‎
Australian scientists have identified a molecule which controls inflammation in the brain, offering hope of a future treatment for conditions such as ...
Parkinson's. A study from Sydney's Garvan Institute has found that nerve cells in the brain produce an anti-inflammatory molecule that triggers the brain to repair itself.

Lead researcher Dr Bryce Vissel says they found that giving over the counter anti-inflammatory drugs to mice could allow brain regeneration.

xxxxxxxxxxxxxxxxxxxxxxx

edit *copyright article*

sounds promising.... http://www.sciencealert.com.au/news/20090306-19256.html

[lurkingforacure]

Originally Posted by Ibken

Are you self-medicating - or following an Md's RX? Any 'side effects' so far?
What does Benadryl do - act as an anti-infllammatory?

ibby

I think a lot of folks take Benedryl for the same reasons others take LDN, it appears to slow progression in some people, and help symptoms as well. We take it because it helps with sleep. It definitely has not stopped our progression, though, and I cannot say it helps with symptoms, either, but it is helping others much more significantly. There have been several posts about LDN on the forum, if you search they should come up.

I saw this article too and it is one more thing tying inflammation into this whole PD mess. It just keeps coming up....we have wondered if you took a shot of cortisone in the brain what that would do, since it is such a powerful anti-inflammatory???? That's similar to what they did with that rhumatoid arthritis drug for alzheimer;s, injected it into the neck and those folks improved immensely within minutes....doubling their cognitive score on the mental exam. I'm not sure if anyone is pursuing that research, though, since that drug, we were told by our neuro, can cause MS-like side effects. The point though, is that inflammation seems to be the culprit, again.

[kenki]

Following on from previous post I came across a reference to Benadryl as a prophylactic for mild PD.

"Benadryl is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease." from Drugs.com

[Ronhutton]

I did a quick search and came across the following info.
It is only available for research
Ron

Recombinant Human Activin-A

Description :
Activin-A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin-A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin-A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin-A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

Catalog #:
003-ACTIVINa

Source :
High-5 (BTI-Tn-5B1-4) Insect Cells

Formulation :
The sterile filtered solution was lyophilized from 50 mM Citric Acid, pH 3.0.

Stability :
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -800C.
Reconstituted Human Activin-A should be stored in working aliquots at -800C.

Purity :
Greater than 95% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Reconstitution :
We recommend a quick spin followed by reconstitution in water to a concentration of 50 µg/ml (e.g., 5 µg/100µl) will yield a solution of 10 mM Citric Acid, pH 3.0. This solution can then be stored at room temperature or at 40C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml albumin and stored at -800C.

Biological Activity :
The ED50 was determined by ability to inhibit the murine MPC-11 cells. The expected ED50 is 0.5 - 2.0 ng/ml.

PubMed Link :
Activin-A Human

Usage:
For research Purposes Only - Made using a cell BTI-Tn-5B1-4 under license from the Boyce Thompson Institute for Plant Research, Inc. Not for use in diagnostic or therapeutic procedures.

[girija]

Thanks for posting this information and thanks ROn for Activin A info.
This is so interesting and fits very well into what is already known.
Inflammation and immune dysregulation seem to be major promoting factors for PD. Microglia and T cells are the culprits for inflammation in PD. Several papers show that the presence of TGFbeta promotes T regulatory cells, these cells in turn dampen the microglial activation and this could potentially slow down PD. T reg cells seem to control everything, autoimmunity, cancer, inflammation and what not! Its time for cell therapy......
Cannot help it but say.......I wonder how much its going to cost for such therapies???

Girija

Originally Posted by Ronhutton

I did a quick search and came across the following info.
It is only available for research
Ron

Recombinant Human Activin-A

Description :
Activin-A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin-A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin-A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin-A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

Catalog #:
003-ACTIVINa

Source :
High-5 (BTI-Tn-5B1-4) Insect Cells

Formulation :
The sterile filtered solution was lyophilized from 50 mM Citric Acid, pH 3.0.

Stability :
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -800C.
Reconstituted Human Activin-A should be stored in working aliquots at -800C.

Purity :
Greater than 95% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Reconstitution :
We recommend a quick spin followed by reconstitution in water to a concentration of 50 µg/ml (e.g., 5 µg/100µl) will yield a solution of 10 mM Citric Acid, pH 3.0. This solution can then be stored at room temperature or at 40C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml albumin and stored at -800C.

Biological Activity :
The ED50 was determined by ability to inhibit the murine MPC-11 cells. The expected ED50 is 0.5 - 2.0 ng/ml.

PubMed Link :
Activin-A Human

Usage:
For research Purposes Only - Made using a cell BTI-Tn-5B1-4 under license from the Boyce Thompson Institute for Plant Research, Inc. Not for use in diagnostic or therapeutic procedures.