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07-24-2009, 11:04 AM | #1 | |||
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Magnate
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A member of PLM posted this data. We I inquired about posting it in another board (other than PLM) he state that the data was public domain, so here it is.
To date, they have compiled some interesting facts about the PD community and its members:
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You're alive. Do something. The directive in life, the moral imperative was so uncomplicated. It could be expressed in single words, not complete sentences. It sounded like this: Look. Listen. Choose. Act. ~~Barbara Hall I long to accomplish a great and noble tasks, but it is my chief duty to accomplish humble tasks as though they were great and noble. The world is moved along, not only by the mighty shoves of its heroes, but also by the aggregate of the tiny pushes of each honest worker. ~~Helen Keller |
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"Thanks for this!" says: | rose of his heart (07-25-2009) |
07-24-2009, 05:20 PM | #2 | ||
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Member
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Quote:
The test identifies, among other things, the LRRK2 mutation associated with specific populations of late onset PWP. It does not assess the Parkin or Pink mutations associated with early onset PD. (I verified this with 23andMe.) Additionally, as the quote implies, there are likely other mutations that remain unidentified which are somehow linked to PD, as well as SNIPS. This is in no way a criticism of 23andMe's invaluable service. It's just a reminder to participants that if your results show no mutation of LRRK2 that does not necessarily mean there is not a genetic component to your PD. Your doctor may agree to order additional testing from a private lab if you are interested, and some insurance companies will pay for it...mine did. But beware of the billing tricks labs sometimes play with consumers (I'll save that shocking tale for another day!). These tests run in the thousands and, as of yet, have no or little practical application. My newest silver lining of PD: I finally understand why my eyes are blue! Rose |
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07-24-2009, 08:20 PM | #3 | |||
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Senior Member
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Rose, I really enjoy your posts both here and at YOPA. Best, Laura |
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"Thanks for this!" says: | rose of his heart (07-25-2009) |
07-24-2009, 08:50 PM | #4 | ||
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Member
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I participated in 23andM3 research project too, mostly because my data point would add to PD knowledge, not for immediate personal benefit. I was also aware of the fact that they are doing just LRRK mutation analysis. I assumed that it is because the project is Google funded and LRRK mutations in PD are of interest to Google founder. Yes, it would have been a far better study had they included other genes too. May be they will at a later date.
Thanks for pointing out that absence of a genetic marker does not mean anything. Sadly, finding a mutation doesnot translate into a cure either. At this point, this project is mostly for science and data collection. It will help future generations, I hope. girija |
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07-25-2009, 06:48 AM | #5 | ||
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Member
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Another immediate benefit I had initially selfishly hoped for (before learning that there are likely more markers we are unaware of than the ones we know) was peace of mind. My maternal grandmother had early onset PD and I suppose I was looking for a reason not to be terrified that my two boys will develop it as well. I worked in fundraising long enough to know that most people's motivations to contribute to anything are multi-layered. The closest to an exception I have found are the Anonymous Altruists. The rest of us fall somewhat short of that. In the end, actions count more than motivation. The data will be useful either way. Selfish Rose ;>) |
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07-25-2009, 12:49 PM | #6 | ||
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Member
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Hi Rose,
I didnt realize how my post sounded till I read your post! That post was written after a long philosophical discussion with friends who are visiting us! After a glass of wine, chatting with good friends who have known us for 20 years and share similar ups and downs in life and remembering how we all wanted to do science for the sake of science.........you can guess my frame of mind!! The other selfish part of me (I do have one!!) was relieved to see that there are no mutations in my LRRK. Just as you said I was concerned about my kid too. There! now you know! girija Quote:
Last edited by girija; 07-25-2009 at 01:13 PM. |
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"Thanks for this!" says: | rose of his heart (07-25-2009) |
07-27-2009, 08:47 AM | #7 | ||
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Member
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The reason that LRRK2 is the only gene mutation on the current chip is because the service is only able to identify common mutations for common diseases...so, by their rare nature, other genes won't likely be read/detected at the current chip strength. As it is, LRRK2 is only expected to be found in 1 to 3% of sporadic PD cases (higher percentages in some ethnic populations) --making it the mutation that, thus far, explains the "most" about genetic etiology of PD. This is technology driven not, driven by a limited interest in LRRK2 only thing.
As technology improves and the cost of computing comes down over the coming years, then such tests will likely be able to report on more rare mutations (not just in PD but in across all diseases). Right now this limitation is related to the difference between a SNP analysis and a full genome-wide assessment. Debi |
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07-27-2009, 12:21 PM | #8 | ||
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Member
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Debi,
Thanks for clarifying the reason for LRRK2 detection. My post is not appropriate for the general forum and I am trying to edit it. A good lesson for me to learn, when not to post and to re-read what I wrote!!! Girija Quote:
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07-27-2009, 03:29 PM | #9 | ||
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Member
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This is what it says next to my little elevated risk for PD item - it appears to be genetic:
"Since the G6PD gene is located on the X chromosome,...." has anyone ever heard of this? apparently it is a good thing i have never had fava beans, as they have a tendency to burst the red blood cells of people with this deficiency. boann |
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07-27-2009, 05:39 PM | #10 | |||
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Magnate
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Girija, after a period of time the "edit" button goes away and you have to contact a moderator to fix the post or to delete the post.
Carolyn
__________________
You're alive. Do something. The directive in life, the moral imperative was so uncomplicated. It could be expressed in single words, not complete sentences. It sounded like this: Look. Listen. Choose. Act. ~~Barbara Hall I long to accomplish a great and noble tasks, but it is my chief duty to accomplish humble tasks as though they were great and noble. The world is moved along, not only by the mighty shoves of its heroes, but also by the aggregate of the tiny pushes of each honest worker. ~~Helen Keller |
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"Thanks for this!" says: | girija (07-27-2009) |
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