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Old 12-21-2009, 04:05 PM #10
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mrsD mrsD is offline
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Nitrous exposure is not necessarily "toxic" in the same sense as other toxins because one normal exposure is enough to damage B12 actions in the body. Toxic usually applies to toxins/poisons, which need high doses say of Tylenol which can be toxic, or are not compatible with life such as pesticides/nerve gases/heavy metals. The B12 inactivation for nitrous was discovered long after it was in use for many decades. It is not commonly used now because of that.
So instead kids go to raves and huff it from balloons! But some hospitals still use it... they haven't kept up! Nitrous is NO, the nitrogen is very reactive and that is how it does its damage.

Quote:
Nitrous oxide inactivates the cobalamin form of vitamin B12 by oxidation. Symptoms of vitamin B12 deficiency, including sensory neuropathy, myelopathy, and encephalopathy, can occur within days or weeks of exposure to nitrous oxide anesthesia in people with subclinical vitamin B12 deficiency.[citation needed] Symptoms are treated with high doses of vitamin B12, but recovery can be slow and incomplete.[34] People with normal vitamin B12 levels have stores to make the effects of nitrous oxide insignificant, unless exposure is repeated and prolonged (nitrous oxide abuse).[citation needed] Vitamin B12 levels should be checked in people with risk factors for vitamin B12 deficiency prior to using nitrous oxide anesthesia.
from http://en.wikipedia.org/wiki/Nitrous_oxide

Nitrates and nitrous have different chemistries. I have not seen any reports of nitrates used therapeutically affecting cobalamin metabolism.

Nitrates--nitrous--- and nitric oxide are all chemically different and different reactively.

http://en.wikipedia.org/wiki/Nitrate
organic nitrates have been used medically for decades with no connection to neuropathy directly. The conditions they treat may lead to poor circulation and hence PN but that is a very indirect effect, mostly in the elderly. Nitrates induce tolerance to vasodilation, and lose their effectiveness over time with daily doses. I really don't think your poppers are your culprit.
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Last edited by mrsD; 12-21-2009 at 04:25 PM.
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