Thanks Billye. That is a great article. It's a review of several clinical studies using patients with either prediabetes or diabetes and PN. The studies explore the effects of glucose control alone compared with glucose control with diet changes and exercise in reducing pain and reducing or reversing peripheral nerve damage.

There was no improvement in reported pain relief and nerve density as determined by punch skin biopsy in the groups that had placebo only, or glucose control with Metformin as compared to groups that also had diet control and exercise. The diet control and exercise groups had reduced pain, reenervation, and improved glucose tolerance.

This is highly significant because the neurological community generally believes that PN is progressive and irreversable. We are ahead of that curve, because we know from peoples' experience in this forum that that isn't necessarily true.

We need a separate thread in the stickies containing research reports or summaries and links to them of factors that stop the progression of PN damage, or that promote healing and reenervation.