I will report it, Mrs. D, thanks.

She started me at 75 at bedtime, after taking 600 of gabapentin am and 6 hours later.

I do have to mention that I am prone to depression anyway, have previously been hospitalized for it. Possibly it's my chemical makeup - . Surprised me, though, as I have been on many different antidepressants and never had such a reaction.

And, no, I don't take any now, so it couldn't be that kind of interaction.

Anway, thanks for all the input here - my sister is a nurse practitioner and I discussed this with her last night - said she will use caution when prescribing to her patients with history of depression in the future.

It is not an antti-depression med like Cymbalta.
It is a anti seizure med.
Equivalence is 300mg Lyrica=1800 gabapentin
(1/6 ratio - 75mg Lyrica would equal 450mg gabapentin)
That would equal 600+600+450= 1650
You may have been over your limit for the time period.

Thanks for the dosage comparison chart, Bob.

Didn't mean to say it is an anti - d; just after all the anti d's they have put me on over the years, none seemed to send me into a tailspin; at the most they did nothing.

Just was surprised at the reaction. But hey, will talk to doc, back off on the gabapentin and perhaps give it another go.

Maybe the doc didn't mention it, but the Lyrica & gabapentin have to be totaled together to see what your total intake is. that's the reason for the equivalency.
If you are taking, say 3000 mgs of gabapentin and add Lyroca, you have to back off of the gabapentin to still equal the 3000mgs.
When I switched to Lyrica completely, I had to have a titration chart of backing off gabapentin and adding Lyrica, in increments of 50mg of Lyrica, until I had completely replaced the 4200mgs of gabapentin with the Lyrica. I started with 150mgs of Lyrica and reduced 900mgs of the gabapentin. It took about 10 days.

I have painful burning and the Head neuro at Bangkok hospital put me on 300mg of Lyrica and 25 mg nortriptolyne straight up. I was in La La land for a week.
Didnt tell me that I needed to titrate down if I quit so I quit cold turkey and had zero side effects probably because I didnt know there were any LOL.

IMO there would be many on Lyrica at way to higher dose. I get the same relief on 75mgs that I got at 300mgs and feel pleasantly light headed.

I dont have any side effects from Lyrica and love it

Thanks again, Bob, yep, I think the titration is off. She gave me a schedule which would have gone like this:

Day 1 - am 600 gab., pm 600 gab., hs 75 Lyrica

Day 2 - am 600 gab., pm 75 Lyrica., hs 75 Lyrica

Day 3 - Lyrica, Lyrica, Lyrica 75 mg each.

Sounds a little too quick????

I think that a 3 day switch is too quick .
At least 5-7 days, keeping you at an interval
so you have at least one day in-between,
and at a lower 50mg increase
2-3 days in-between would be a conservative
and cautious titration for the switch.
I think that the body needs time to adjust,
and you need to keep watch for s/e at the intervals.