if we get injured....

Mere · 06-02-2010, 01:45 PM

Everything is very painful to me - even stimuli that most people would not find 'painful'. Sometimes referred to as the "Princess and the Pea" syndrome. No, it's not really called that...

Is it possible that you suffer from fibromyalgia? It is one of those nasty things that like to piggyback with other illnesses such as autoimmune disease, neuropathy, etc... It has a tendancy to "amplify" pain sensation.

I have that problem. Dental work always poses a problem with me - fortunately, my dentist administers nitrous oxide gas.

Hope you feel better.

Mere

mrsD · 06-02-2010, 03:02 PM

Nitrous destroys B12. I have read that just one treatment with it can disrupt B12 metabolism!

Quote:

Nitrous oxide inactivates the cobalamin form of vitamin B12 by oxidation. Symptoms of vitamin B12 deficiency, including sensory neuropathy, myelopathy, and encephalopathy, can occur within days or weeks of exposure to nitrous oxide anesthesia in people with subclinical vitamin B12 deficiency.[citation needed] Symptoms are treated with high doses of vitamin B12, but recovery can be slow and incomplete.[57] People with normal vitamin B12 levels have stores to make the effects of nitrous oxide insignificant, unless exposure is repeated and prolonged (nitrous oxide abuse).[citation needed] Vitamin B12 levels should be checked in people with risk factors for vitamin B12 deficiency prior to using nitrous oxide anesthesia.

A study of workers[58] and several experimental animal studies[59][60][61][62] indicate that adverse reproductive effects for pregnant females may also result from chronic exposure to nitrous oxide.

http://en.wikipedia.org/wiki/Nitrous_oxide

http://www.ncbi.nlm.nih.gov/pubmed/17404524

Quote:

Rev Neurol (Paris). 2007 Mar;163(3):362-4.
[Nitric-oxide triggered neurological disorders in subjects with vitamin B12 deficiency]

[Article in French]

Cohen Aubart F, Sedel F, Vicart S, Lyon-Caen O, Fontaine B.

Assistance Publique-Hôpitaux de Paris, Fédération des maladies du Système Nerveux, et Université Pierre et Marie Curie, Groupe Hospitalier Pitié Salpêtrière 47-83 boulevard de l'hôpital 75013 Paris, France.
Abstract

INTRODUCTION: Nitrous oxide is frequently used for anesthesia. It may cause spinal cord toxicity. CASE REPORTS: We report two patients who presented gait disorders after nitrous oxide anesthesia. Physical examination revealed arms and legs pyramidal syndrome and abnormal proprioception, consistent with subacute combined degeneration of the spinal cord. Serum vitamin B12 level was extremely low. The patients improved with parenteral treatment with hydroxycobalamin. CONCLUSIONS: The inactivation of methionine synthase and L methylmalonylcoA mutase by nitrous oxide has been previously demonstrated. Anesthesia-related exposure to nitrous oxide may induce neurologic disorders even in patients with no preliminary vitamin B12 deficiency.

PMID: 17404524 [PubMed - indexed for MEDLINE]

As time passes more and more articles appear on this subject, but they were available back in 2000 or so even then.

nide44 · 06-02-2010, 04:14 PM

I always thought that nitrous oxide gas was found to be the cause of PN in many cases.
Documented traces back, to be the only element that preceded the onset
of PN in quite young patients.
I won't let a dentist use it on me.
I undergo all procedures with topical, injected numbness,
or in one instance of severe dental work about 30 yrs ago-twilight sleep.

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