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Old 06-16-2010, 10:18 PM #6
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Location: Oklahoma USA
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Electron Electron is offline
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Join Date: May 2010
Location: Oklahoma USA
Posts: 263
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The following article suggests that "tricyclic antidepressants might deplete the body of coenzyme Q 10 (CoQ 10)." Perhaps a mechanism by which amitriptyline could cause neuropathy. BTW I have been taking it for a few years, mainly 25 mg/day, and it helps with my pain level. If it were slowly making it worse, I might never know. You can find alternatives, there are many drugs used to relieve painful neuropathy. It seems one of the premier ones is gabapentin (Neurontin).

I can't post links yet, so go to **
and search for "Tricyclic Antidepressants"

"Coenzyme Q10(CoQ10)

Preliminary evidence suggests that tricyclic antidepressants might deplete the body of coenzyme Q 10 (CoQ 10), a substance that appears to be important for normal heart function.1,2 Based on this observation, it has been suggested (but not proved) that CoQ 10 supplementation might help prevent the heart-related side effects that can occur with the use of tricyclic antidepressants."

Good luck
BasicPoke
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