Hello, David... Did you not see the other thread? If you have serious concerns about the aspirin, you can try AlkaSeltzer Gold. (no aspirin in it).
The other alkaline buffer available is TriSalts
http://www.bio-tech-pharm.com/products/trisalts.html (the powder is stonger).

Aspirin in solution like AlkaSeltzer is absorbed very quickly from the stomach..it does not linger around to cause bleeds, like tablets do.

Aspirin taken systemically does reduce platelet activity to some extent. So systemically it would be additive with other drugs that thin the blood or affect platelets: SSRI antidepressants, Plavix, Pletal, warfarin,
Here is a fuller list of drug interactions, pro and con:
from http://www.rxlist.com/cgi/generic/asa_ad.htm

The thread to which I am referring was on OBT chronic pain...
http://brain.hastypastry.net/forums/...ead.php?t=8553
and
http://brain.hastypastry.net/forums/...ead.php?t=8265

AlkaSeltzer will also block histamine reactions, from foods.
On both of those threads is a link to pain.org about acidic reactions at the
tissue level at nerve endings.

If you have some issue with the aspirin, you can ask your doctor. Aspirin prophylaxsis for CAD is either 81mg /day or 325mg/day depending on the doctor. Combined with other medications, is the most important thing to
consider. However, aspirin remains a treatment for many inflammatory conditions today, and even is basic to RA treatments, still today.

Aspirin affects lipid peroxidases, but does not control lipid levels to the best of my knowledge. These are different things.

If one already has erosions in the stomach (AlkaSeltzer would not reach the small intestine in appreciable amounts like tablets would) then bleeding could occur. To intact mucosa? Not much risk. People who have constant GI issues like GERD, typically have poor mucosal lining, due to long term EFA depletion, or infections with H.pylori. These patients would do better with TriSalts or AlkaSeltzer Gold.

Here is an article about tablet form of aspirin in the 81mg-325mg dose range:
http://gastroenterology.jwatch.org/c...ull/2003/128/1

Here is an old paper illustrating the difference between acidic solutions, and basic ones:
http://www.springerlink.com/content/v844n8771p26g082/
and this from Rxlist.com
http://www.rxlist.com/cgi/generic/asa_ad.htm

AlkaSeltzer is just not like taking aspirin TABLETS in any form. It does not stay in the stomach long enough to irritate it.

Here is another paper...
http://jada.ada.org/cgi/content/abstract/93/1/111

I will add that some researchers do not trust enteric coating at all. It breaks down in the intestine, and a bleed can occur there, just as easily as in the stomach if the concentrated tablet does not dilute out quickly.

When you take any aspirin product, or NSAID (Feldene and Indocin are the worst, but any can do it)...a bleed can occur where there is an erosion, inflammation of the GI mucosa due to any reason. Most the GI bleeding from NSAIDs (and some of the aspirin) is due to SYSTEMIC suppression of platelets, that the drugs cause. This has a time factor... and does not occur at the
very beginning of therapies.

You can get a bleed from that 81mg tablet of aspirin as well, enteric coated or not.

So if you are concerned then, I'd go for the AlkaSeltzer Gold or TriSalts to get the acidic buffering benefit. I like the aspirin because I have pain anyway.
And even with my GI issues and hiatal hernia I have never had a bleed or incident. I also let the bubbles go flat before drinking...to minimize reflux or burping.

This is some detail... and I hope it answers your questions. Any further, just post them here. Remember there are NO guarantees with ANY drug therapy on the planet.