The new podiatrist prescribed Prudoxin (generic form of Zonalon) which is used primarily for itching but he says it is great for burning/numb feet. Guess what? He's absolutely right! The main ingredient is 5% doxepin hydrochloride and the only side effect listed is "drowsiness," which I haven't noticed as I use it at bedtime.

I think of this as a miracle cream for my achy, burning, numb feet. It costs $30 (my copay) for a small tube but I use a tiny thin film of it.

I'm using Biofreeze for my ankles & calves which are not as painful as my feet.

I look forward to your opinion of the new Tylenol cream. Might be a less expensive replacement for Prudoxin.

WalMart had it.... for 7.97 for 2.5 oz.

I will try it tonight on my knee and feet and see what happens.

It does look nice to me. The methyl salicylate is very high % and because of that covering large areas would be potentially harmful (like the poor girl who died overusing BenGay recently).

I already use regular Salonpas, with some success, so I am eager to try this cream as well.

Thanks for the Zonalon info. That product came out a long time ago, and never really became popular when I was working.
$30 for a copay for a generic seems steep!

Back many ages ago when I had a severe sciatica attack (working midnights), I used doxepin orally for about 6mos. It worked well that way too. It is a TCA with less side effects than the others. I used 20mg (the antidepressant doses started at 100mg daily).

Online Walgreen's shows they have Precise, but checking by zip code our local store showed out of stock. I called CVS and they did not have it.
But the WalMart by me did, and it did NOT show on their website though. It seems quite new.

If you google "tylenol precise cream", you will see that there are coupons available for this product at CVS. I'm going to wait for more reviews as I have a cabinet full of topical stuff that hasn't worked for my burning feet. But I sure do hope it turns out to be helpful!

what does it do for the numbness?

I don't expect much for numbness. But you can never tell.
If the numbness is because the nerves are "dead"... that will be it.

But I have transient numbness in my hands (carpal tunnel) and feet, which comes and goes depending on compression issues.
Too tight shoes =numbness
gripping the steering wheel for long periods and my hands go numb. Some gloves will make my hands numb too.

So for this transient type, perhaps this type is more "inflammatory" etc, and may respond to the Precise.
I have more pain and burning than numbness overall.

The Zonalon might work for numbness since it is a TCA.
I'd try it if I were you, Echoes. I hope you have insurance as it is very expensive (over $100 for 1.5oz generic cash). I would think you'd know something by the end of one tube.

BTW I was checking my WalMart receipt to make sure I got all my bags...you know that spinning gizmo that keeps some of your purchases sometimes????....anyway my Precise cream rang up at 6.97! (the shelf tag was 7.97 and so is the price tag). Don't know why.

I am putting the cream on my poor finger of the right hand which is giving me grief ...I'll show it to the doctor when I go this fall...but I think it is arthritis. (the middle knuckle is swelling a bit and the finger is very stiff some days, like today).

So Today is a good day, as I've had NO Aleve or Tylenol, and it is a small area to test as well. The oral meds might mask or confound any changes in the stiffness of that finger.

First impressions.... This cream is very unlike Biofreeze. There is no cool sensation from the high menthol, and the cream really needs to be rubbed in for at least 2 minutes. It remains a bit greasy for about 15 minutes and then disappears. The cream is quite fluid... more like a thick lotion IMO. It dispenses out of a tiny little hole in the top of the tube. The tube has a flip top and a special blocking plastic barrel which seals off the opening completely. Looks pretty fancy to me in that regard. So there is no unscrewing a cap.

There is a moderate odor of wintergreen, like Salonpas, but it is less than those patches. I can't really smell the menthol at all.

A little seems to go a LONG way. I will do this finger for several days and report back.

Sounds very similar to my 'Cool Heat'
(generic "Icy Hot" from Rite-Aid)
My 'Cool Heat' becomes more fluid (runny) on hot summer days
and in winter, is more of a cream consistency.

It decreases the numbness and restores some feeling to the soles of my feet. Plus, because the numbness is less, my balance is better as I can actually feel where I am putting my feet. I love love love it.

Sorry if I sound over the top but so far, of all the many creams and potions I've used, this is the best. I wish we could get samples of it so you'd be able to try it without investing big bucks. I found out that the retail price for this is over $120 and that my co pay of $30 is considered "reasonable."

Hi Antonina
I went to my GP and got him to prescribe this cream and am due to start it tonight, I am a little concerned that there is a warning that you should only use for 8 days - have you used this for longer and was it ok?

Just an update.... I've given up the Precise.

I tried my magnets on my stiff finger, right hand. And they did far more than this cream.

I am disappointed that this product created MORE burning with that high menthol %.... compared to Biofreeze for my feet.

I suppose for some aches and pains it will be "okay". But my magnets worked better in the end. After a week even my hand was tingling and burning..which it never does. So I can't give this cream Precise a blanket endorsement!

I do want to keep track of the doxipen--prudoxin (Zonalon) trials however.

Please make a new thread, preferably on the SubForum above if you have successes. Thanks so much!