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Tolerance to Meds.......

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Old 12-17-2010, 02:48 PM #1
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Default Tolerance to Meds.......
As was just pointed out to me the weight gain from Gabapentin can level off.

I was wondering if anyone knows if the potential to build tolerance from it working at a certain dose can also level off, or does tolerance continue to be an issue?
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Old 12-17-2010, 06:44 PM #2
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I'd love to see what people say about this. My Lyrica has to be increased every few days and when I get to the top dose, 600 mg, I'm wondering what I'll do then. My Dr.'s act like I will get to a higher dose where I won't have the tolerance anymore, but I'm becoming less optomisitc about that.

I thankfully just got an appt. with the Chronic Pain Dr. I was referred too. But my appt. is 7 weeks away. But I'm rejoicing I even have the appt. and optomistic she will have some better ideas for my care.
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Old 12-17-2010, 11:33 PM #3
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this is why a number of people wind up being treated for pain with three types of medication at the same time. An anti depressant, an anti convulsant and an opiod such as oxycontin or some other type of pain medication for break through pain. they each block pain in a different way.
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Old 12-18-2010, 03:57 PM #4
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I developed a tolerance for gabapentin after 6+ years taking it. I was up to 4200mgs/day and it no longer was effective. I switched to Lyrica 450mgs/day for 30 days and then went up to 600mgs/day. I've been at 600 for 3+ yrs, now and it seems to be very effective at that level. Dunno what I'll do if it stops being as effective as it is. I feel fortunate to be able to function quite well using it at that dose.
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Old 12-20-2010, 08:53 AM #5
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Quote:
Originally Posted by invisable View Post
I was wondering if anyone knows if the potential to build tolerance from it working at a certain dose can also level off, or does tolerance continue to be an issue?
That's going to be different for everyone. Some people do reach a certain level (I've heard some chronic pain patients refer to this as "the sweet spot") and can remain there for years (like nide44). Others may gradually increase.

Some folks (as echoes noted) attain balance with different combinations; others rotate medications as they build/achieve some level of tolerance.

A good question to discuss w/ your prescribing doctor, along with "What if..." scenarios.

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Old 12-20-2010, 04:29 PM #6
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another route that can be taken and was taken by a poster here, Brian, who is a PN success story by the way, was to titrate down when he became tolerant at a high dosage level and then slowly titrate back up. worked for him.
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Old 12-20-2010, 07:43 PM #7
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600 often? Bid, tid???



600
Quote:
Originally Posted by rose_thorn98 View Post
I'd love to see what people say about this. My Lyrica has to be increased every few days and when I get to the top dose, 600 mg, I'm wondering what I'll do then. My Dr.'s act like I will get to a higher dose where I won't have the tolerance anymore, but I'm becoming less optomisitc about that.

I thankfully just got an appt. with the Chronic Pain Dr. I was referred too. But my appt. is 7 weeks away. But I'm rejoicing I even have the appt. and optomistic she will have some better ideas for my care.
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Old 12-20-2010, 11:37 PM #8
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Lyrica top dose it 600 mg. per Day.
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Old 12-21-2010, 09:45 AM #9
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Some have gone to 900mg/day-but very few docs will Rx that large.
Mostly in trials at that level, but it has been done.
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Old 12-21-2010, 10:01 AM #10
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Default Very Interesting........
Quote:
Originally Posted by echoes long ago View Post
another route that can be taken and was taken by a poster here, Brian, who is a PN success story by the way, was to titrate down when he became tolerant at a high dosage level and then slowly titrate back up. worked for him.
I would never have thought of such an approach. Lots of pain filled days, I'm sure, but very clever idea......Thanks for sharing it!
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