Mrs.D,

This question is directly for you.My neuro believes i have a polyneuropthie from using dapsone.
Everything i can find on the net about a dapsone indused neuropathie indicates that is temporary and that it is motor neuropathie or motor-sensor neuropathie.
I cant find anything about a pure sensor neuropathie that is as long lasting as i have it 1.5 years now.Maybe you can help me out with some more information about this dapsone neuropthie

Sheers

Have you seen this article?

http://www.ncbi.nlm.nih.gov/pmc/arti...1/?tool=pubmed

It is pretty detailed.

No i haven't,interesting the article says it should resolve in some causes after 3 or maybe x years when a patient stopped the oral dose.
I stopped with that around summer 2008

I will look up the metabolism of this drug for you. I can't tonight but I will tomorrow.

If I find a hint, to point us in a supplement direction to help you I'll post it here on this thread.

There may be something you can do to speed your recovery.

Hope so thanks anyway for the help

One thing that dapsone causes in the body is a form of anemia, called methemoglobinemia:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368303/

http://emedicine.medscape.com/article/815613-overview

This changes the heme in blood to Fe+++ which then cannot carry oxygen to tissues. This may be a main cause of the neuropathy... a lack of oxygenated blood.

This link states that some agents used have no "proven" value, but I think they may be worth a try:
http://emedicine.medscape.com/article/815613-treatment
If you no longer take this drug, using the treatment protocols probably are not going to help. (methylene blue, and cimetidine). What I gather is that you no longer take dapsone.

I would do the supplements used to repair myelin:
Omega-3 fatty acids
B6, folate and B12
Using 500mg of Vit C a day can't hurt.
And I'd try the acetyl carnitine + lipoic acid, that support the mitochondria where energy is created in the cells.

The NAC which is n-acetyl cysteine is optional, and is mostly for liver metabolism. If you no longer use the dapsone, I don't know if this is really necessary.

I found one paper suggesting Vit E for dapsone induced neuropathies. Since Vit E is easy to tolerate and is an antioxidant as well, it may be helpful for you. I would choose a form that is natural, and which lists the various types included in it...including gamma E.

example:
note that --ol is in the spelling
from http://www.iherb.com/Now-Foods-E-400...tgels/304?at=0

I wouldn't go over 1000IU daily, and perhaps 800IU would be enough.