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Old 05-29-2011, 09:42 AM #41
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Originally Posted by zorrro13 View Post
Its starting to settle now that I have adjusted and yes agree with your post. That usually means time for a higher dose
What... the ringing in my ears is because I need a higher dose?
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Old 05-29-2011, 02:23 PM #42
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What... the ringing in my ears is because I need a higher dose?
Marty, No no, the ringing in my ears is from the tramadol, when I have taken a higher dose. Have you ever had this with aspirin? Same sound. I meant it was time for a higher dose of Neurontin. Sorry to be abrupt, but your post scared me. I didn't want to mislead you.
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Old 05-29-2011, 10:35 PM #43
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Tramadol does not contain serotonin per se.

But it does act on serotonin receptors. This may be a function of the action it has on mu receptors (pain area) and other receptors like the kappa one.

Some opiates also do this. Oxycodone has quite a serotonin connection in some people.

Some neurotransmitter actions are cascades...initiated by one system and then a second one becomes active. Histamine in the brain is like this, initiating other systems.

The bottom line is that many drugs overlap onto other systems and have actions that complicate things for people.
Some of these are discovered during trials, but many take years and years to come forward, during post marketing.
Thank you for this thorough explanation. Sadly, one of my doctors Rx'd me flexeril while on the extended release formula of tramadol and within a day things were getting weird for me. After a couple of days it dawned on me to check the contents of it and thats when I realized what was happening. Even more sad was the fact that I brought it to the doctors attention. Now I just tell all of them that I won't touch anything with serotonin in it. That was a very scarry situation for me.
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Old 05-30-2011, 08:53 AM #44
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Thank you for this thorough explanation. Sadly, one of my doctors Rx'd me flexeril while on the extended release formula of tramadol and within a day things were getting weird for me. After a couple of days it dawned on me to check the contents of it and thats when I realized what was happening. Even more sad was the fact that I brought it to the doctors attention. Now I just tell all of them that I won't touch anything with serotonin in it. That was a very scarry situation for me.
What is so bad about serotonin?
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Old 05-30-2011, 08:58 AM #45
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Too much serotonin is the issue. Where there is too much action on those receptors serious things can go wrong.

Normally we all have serotonin working for us. There are many types of receptors too, located all over the body. But when you add drugs into the picture, this sensitive system can get overloaded.
And it varies from person to person too. Some people just normally live with high serotonin levels, and those types would be more prone to serotonin syndrome. It is thought for example, psychologically that timid or careful people are high serotonin expressors. Contrasted with high dopamine people who are drawn to excitement and risk taking activities. You won't find many high serotonin types sky diving, for example!
Those with high serotonin systems, often get the worst side effects from SSRI antidepressants.

http://en.wikipedia.org/wiki/Serotonin_syndrome

90% or so of your serotonin is in the peripheral areas of the body. GI tract and platelets mostly.
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Old 05-30-2011, 10:15 AM #46
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Pretty much the same here for me as well. I've been using NB926's. I get them in a 5xwide and a size longer then I wear and mainly use them as slippers. It's mandatory where I work that my shoes be all leather so this has complicated it. But I now have a desk job and when I'm sitting at my desk which is 90% of the time off goes the shoes as fast as I can. When I drive or really anytime I sit down off comes the shoes. Even at church where I'm in a pretty seen position. Everyone knows my problem but it was really hard for me to swallow my pride. It's just that most ppl I've ran into with PN wear shoes so I wonder if I'm worse off then most, that's why I asked. If I had to wear shoes and stand all day at work I would maybe last a month before the pain would break me down to a non functioning employee. Thanks for sharing.
Hey Marty, I'm another bare footer for 6 months now can't wear socks at all and any shoes drive me crazy. At first I got by for short periods wearing either Air walkers or Air Speed Both skate boarders sneeks come very wide and I get extra size also and use as slippers, and off they came when ever I sat also. But now all I wear is flip flops size 12 I have a size 9 foot, anyway you are not alone which now I know I'm not either Thanks
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Old 05-30-2011, 11:16 AM #47
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Since people are "coming out" here as bare footers, I'm wondering about something else...most folks here say that the cold weather is what bothers their feet the most. I'm just the opposite. One thing that really puts me over the edge is hot sun shining on my feet. Going to the beach is really tricky without ruining everyone else's fun. The key is my own big umbrella and a spray bottle. Also, white socks under these circustances can be better than bare feet under sandals/slides if I wet them down with cold water. I don't care if I look stupid.

Is anyone else here sensitive to the heat like this?
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Old 05-30-2011, 11:24 AM #48
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I am very sensitive to the heat. Summer is when I get most of my burning attacks. That is when I hit the Biofreeze the most.
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Old 05-31-2011, 06:52 AM #49
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Default A lot of people--

--especially those with a demyelinating component to their neuropathy, find heat more difficult to tolerate than cold, as heat is the enemy of "clean" nerve transmission, and if one had myelin damage the nerves are not transmitting that cleanly to begin with.

The MS people know this well--and there are many products on the market, such as cooling water vets, that are made primarily for them. And savvy neurologists know that nerve conduction studies are supposed to be done in a relatively cool room.
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Old 05-31-2011, 09:44 AM #50
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Since people are "coming out" here as bare footers, I'm wondering about something else...most folks here say that the cold weather is what bothers their feet the most. I'm just the opposite. One thing that really puts me over the edge is hot sun shining on my feet. Going to the beach is really tricky without ruining everyone else's fun. The key is my own big umbrella and a spray bottle. Also, white socks under these circustances can be better than bare feet under sandals/slides if I wet them down with cold water. I don't care if I look stupid.

Is anyone else here sensitive to the heat like this?
For me winter cold makes me frozen and pain goes up. Summer makes me swell more and pain goes up. When hot I only wear socks about 1 or 2 hours a day and that is by force. I do wear walking shoes though anytime I am on my feet from the pain. I can't walk bare foot.
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