I have painful polyneuropathy, mainly in my chest, back, neck and jaw.

Over a 2 year period, I've titrated up from 30 mg Cymbalta to 120 mg. It worked great until recently. I'm clearly at the top of the dosage so I can't take more. In fact I'd like to reduce the dosage and add something else that would be compatible.

Unfortunately I'm sensitive to Lyrica/Neurontin/Gabapentin, so I can't take any of them.

Anybody out there on Cymbalta and another drug? Anybody else have any advice?

Thanks in advance.

Well I am on Cymbalta,Serequil,Neurontin,klonopin. I have been weaning off the dose because I am not feeling any benefits mind or body. Everyone is different.
Have you tried elavil? When I was having a hard time with meds I tried that one. Also for me for ex when I first tried neurontin I had a hard time with it but the dose was too hgih to start and also the side effects lessened after a few days.
Sorry I don't have more advice. Have you seen a pain doctor? I would because they work better with pain control then neurologists or gp I feel.

I have just tried Tramadol for break through pain . Extremely effective but not sure about the cymbalta mix.

You know its interesting that neuro surgeon dr Wise Young recommends elavil as the first choice in P/N pain Its also one of the cheapest.

Since elavil is low dose approx 25mg I doubt it would interact to much but Im no doctor, best of luck surely you will find something that will help.

I would be concerned about taking Elavil and Cymbalta together.

This could lead to serotonin syndrome.

You could discuss tapering off the Cymbalta... this drug is toxic to the liver in some people, and if it is not doing anything positive for you anymore, you need to consider dumping it.

Some patients have a difficult time tapering off Cymbalta, so be prepared for that.

I am sorry I have no clue about drug interations but just a med that maybe you could try instead or ask your doctor about.

I'm interested that you take Seraquel as part of your drug regimen. Does it seem to help the pain?

I know it's very, very hard to go off Cymbalta - have read all the horror stories - so I hope I can continue taking it, though at a lower dose, no matter what. It has helped the mental anguish as much as the physical pain.

When I was on a lower dose of Cymbalta my doctor at the time prescribed Elavil 10 mg at night because I was having a very difficult time sleeping. My current doctor doesn't want me to mix Cymbalta and Elavil for the very reason you give - risk of serotonin syndrome.

I do get a benefit from Cymbalta; it's just not as great as it used to be, and I imagine its painkilling properties will continue to fade. It has been enormously helpful as an antidepressant and antianxiety medication, and those effects seem to be holding.