Sorry to post 2 times in a row, but, I am also one of those 'rare' cases who had a hideous reaction to Zofran (an SSRI type drug to stop nausea) and boy was this a doozy....movement disorder for days....and to make matters worse, the usual treatment is Benadryl, which does the same thing to me.

When I see some one not getting the prescribed effect from a drug, I wonder if they are not metabolizing or metabolizing too fast. That is when I look at what else they are one, to see if there is any one enzymatic pathway 'plugged' up, ala 'drug interaction'. More often than not, when it comes to pain treatment, an SSRI is involved.

There has been talk of how much tramadol is to much and the effects on the liver. My average is 150-200mg per day and really helps with the burning.

My thoughts are no point spending years in Pain and checking out with a pink super healthy liver, you cant use it when your gone!

As a matter of interest check out this tramadol abuse forum. keep in mind a vast number abusers are middle class . some of the doses are scary

http://www.medhelp.org/user_journals...y-Room-Part-14

I've been taking Tramadol for over 10 years, along with Lyrica
(previously with neurontin).
I take 100-150 per dose for a max of 300-400mg/day.
It sure helps me & I haven't seen a tolerance issue.

I would eat raw yak liver if it would cure this.

When researching Tramadol I found evidence that it also has anti depressant properties. This is a side effect as tramadol is not prescribed for depression that I am aware of

This may explain why its so abused, simply pop a few and get the lift you need. also explains why its so difficult to wean off.

Great for us that are genuine as it effectively gives 2 for the price 1.

Certainly I dont think about much when Im taking it and Im usually a big thinker.

I agree! It does give some a big happy boost and that's is hard to not want all the time.