As I have been evaluating the supplements I use in my holy crusade to help halt the progression of my PN, I found an interesting article regarding the use of folate and L-methylfolte.

*edit*

I apologize if this article has already been brought up and discussed. I haven't seen it in any of the threads I've read.

The article is filled with information on this subject and goes into discussion of other diseases as well.

One of the sections that stood out for me talks about how folate acid may compete with L-methylfolate at the blood brain barrier. There is reason for concern that folate could block L-methyfolate transportation.

I happen to take folate acid which is in my B complex with L-methyfolate at the same time during the day. This could be causing a problem in getting the proper amount of L-methylfolate into my system due to competion between the two supplements.

I am now taking the B-complex in the morning and the L-metylfolate in the afternoon with my B12 sublingual. I believe that serum levels of the folate acid will be low enough at that time where the L-methylfolate will be fine entering the body through the blood brain barrier.

I have had some strong reactions when first taking L-metylfolate which suggest I was deficeint in this nutrient. This nutrient has been os special interest to me.

I am passing this along for others to consider. Perhaps someone more knowledgable than me can comment.