Jan, you are going to want to start slowly with the R-lipoic.

Perhaps take it every other day for a week or so, until you think you can handle it daily. (this would be the 100mg) and take it in the morning.

It may lower blood sugars, and if you have palpitations, it might aggravate that also. I started at 50mg a day... back when.
And I cannot really tolerate more than 100mg a day now.

A couple of posters here have had the same experience, but the majority don't seem to have a problem with it at all.

So just go slowly in the beginning.

FWIW, I tried going from 100 mg to 200 mg. I experienced no problems whatsoever, but there were no appreciable benefits by raising the dose either, so on that basis (and additional cost) I dropped back down to 100 mg without incident. In my mind this just supports that:
1. Everyone's sensitivity/response to RLA is different, and
2. More isn't necessarily better.

I do wish it worked for everyone as well (and as quickly) as it has worked for me; IMO it was the turning point.

I have since experienced additional benefit when I added pantothenic acid (B5), verified by stopping & starting it again. What I get from this is, if the RLA doesn't seem to help any, I'd try adding B5 before abandoning it altogether (I don't know of any evidence that B5 alone would help unless one were deficient in it, which would be possible, but unlikely/rare).

Best wishes,

Doc