This is long shot but do you find the progesterone makes it worse? The reason I ask is that in October, I started on bio-identical hormones. First with an estrodial patch for two weeks and then I was to start Prometruim 100 mg at night (oral bio-identical progesterone).

In about four days after starting it, any joint issues I had got worse and my feet would ache. I don't have PN but I do have some joint/tendon/muscle issues and found oral progesterone aggravated it. Once I stopped, I returned to my normal aches and pains.

I switched to a topical bio-identical and that does not have the same effect on me.

I think hormones, bio-ident or not, cause some fluid retention.

Fluid = more pain IMO. Pressure on nerves all over the place.

I got headaches from progesterone, I took for 2 yrs at the end of my monthly cycle for heavy periods (a pre-menopausal common complaint)... I rarely get headaches! I ended up switching to another kind but Prometrium wasn't out yet... I used 1/2 the dose and that was better. I used in the end --Aygestin.

I use a bio-identical cream-based progesterone. My periods were getting more and more irregular. Coming up to 44 days apart. And a lot of my other problems seem related to my cycle. So I went to a hormone doc and my test said I was low in progesterone. However, at the time of the test, day 21, I do not believe I had ovulated yet... as that month I went 40 days. I'm also not on a large dose, but I'm on it from day 6-26, usually used for menopause.

I used the progesterone for the last night Friday. Saturday my legs hurt terribly. Sunday my legs were great. Then today (overnight) I started cycling on time which I really am hoping for. Today I actually went to work with my husband in which I was walking all over up and down on grass, lifting stuff, I couldn't believe how good I felt. However tonight my legs have been bad, and I've had tingling on my face and arms, something I haven't felt for a while. I must have tuckered myself out. It also started raining this evening.

So not sure about the progesterone, seems to be okay? I may need the dose adjusted though.