I have been taking Miralax since the first year of my condition for constipation. I take percocet and oxycontin and a few other meds that all add up to constant constipation, so Miralax is the only thing that works. But since I have been taking it from nearly the beginning there has been no recognizable difference in my pn. Perhaps it does help and I don‘t see it. I also used it with my youngest child who was constipated from birth. We used suppositories until she was a toddler and then I used apple juice, or Miralax when there was extreme conditions. She never was dependent on it and now she has grown out of the problem (too long of a colon) finally at age 5 ½. Dr, Smith - thanks for you links and information it I appreciate these tidbits a lot!