difference in ala and rla

Idiopathic PN · 04-07-2012, 04:33 AM

Quote:

Originally Posted by mrsD

SAMe does not have aspirin or NSAIDs in it.

Take the thyroid, wait 1/2 hour and then take the lipoic and SAMe. Since you are fluctuating with the levothyroxine, take it alone, for insurance. With a full glass of water it should leave the stomach in about 1/2 hour and move along.

The SAMe does not dissolve until the intestines. It has a special coating. That takes time, so the thyroid should have moved along by then. You can take the lipoic, B12 and SAMe together.

Wait another 1/2 hr or so before eating.

SAMe is made in the body from homocysteine, using the 3 vitamin cofactors and glycine (which supplies the methyl group).
Once it gives up the methyl group, it is regenerated using the 3 B vitamins over and over. Some people fail in this step with age, so taking it as a supplement repairs that.

I'd start with a small package of 200mg... a 30 pack. Take one a day for a month. See how you feel. You should notice mood effects within the first week. But the effects on joints may take a month or two and then are slowly progressive in a positive way.

This link explains the chemistry:
http://einstein-syndrome.com/biochem...#MTHFRMutation

It gets complicated. But... if you do respond well to SAMe, it might point to a DNA test for the MTHFR problem for you.
This link also shows the interlinking of the methylation chemistry to each other.

Dear Mrs. D,
Thank you so much for your reply and information.

But, I am sorry I forgot to ask you last night - as you may know, I am taking Gabapentin, is there any "sedatives" component of Gabapentin that may have interaction with SAMe?

Thank you very much.

mrsD · 04-07-2012, 07:38 AM

SAMe does not have any interactions that I know of.

The only warning it carries is for bipolar patients, who might get
hyped up on it and not realize. But even then it is a mild warning, not a big one.

Here is a long monograph:
http://www.umm.edu/altmed/articles/s...ine-000324.htm

I don't think it will have any negative effect on the gabapentin, and may in fact improve your cognition which is a common side effect of gabapentin.

It is really a great supplement and just a few months ago had the price decrease, at Costco's. I joined Costco in fact over a decade ago, just to buy it---since it was lower price there. All the money I saved payed for my membership several times over in fact back then.

There is a guarantee on NatureMade's website...if you don't like it you can return it (free shipping) for a full refund, with receipt and unused portion.

The drug interactions listed are the same as for serotonin increasing drugs. But since the SAMe is not increasing it so high like drugs do, the warning is basically a "cover your butt" warning. For people taking SSRIs or SNRIs, the warning is germain and should be followed however.

I didn't find SAMe much help for my PN, so I don't bring it up here often. But it is very good for joint and tendon issues.

Idiopathic PN · 04-07-2012, 08:12 AM

Quote:

Originally Posted by mrsD

SAMe does not have any interactions that I know of.

The only warning it carries is for bipolar patients, who might get
hyped up on it and not realize. But even then it is a mild warning, not a big one.

Here is a long monograph:
http://www.umm.edu/altmed/articles/s...ine-000324.htm

I don't think it will have any negative effect on the gabapentin, and may in fact improve your cognition which is a common side effect of gabapentin.

It is really a great supplement and just a few months ago had the price decrease, at Costco's. I joined Costco in fact over a decade ago, just to buy it---since it was lower price there. All the money I saved payed for my membership several times over in fact back then.

There is a guarantee on NatureMade's website...if you don't like it you can return it (free shipping) for a full refund, with receipt and unused portion.

The drug interactions listed are the same as for serotonin increasing drugs. But since the SAMe is not increasing it so high like drugs do, the warning is basically a "cover your butt" warning. For people taking SSRIs or SNRIs, the warning is germain and should be followed however.

I didn't find SAMe much help for my PN, so I don't bring it up here often. But it is very good for joint and tendon issues.

Oh, thank you Mrs. D!!!

I asked because of that warning on people taking anti-depressants. I am not taking anti-depressant medicines but due to the "grogginess/sleepiness/fogginess" effect in my brain of the gabapentin ----- oh well, just wanted to make sure. AND, its very good that you are around whom we can turn to - always.

I will buy NatureMade brand and try for a month. Let us cross our fingers....

Shezian · 04-12-2012, 11:22 PM

Read through the thread roughly, and sorry am still confused which is the better one to use?

Sue

mrsD · 04-13-2012, 02:46 AM

R-lipoic stabilized is the best one to use now.

example:
http://www.iherb.com/Doctor-s-Best-B...-Veggie-Caps/4
100mg a day to start of this type.

If you choose others non-stabilized you will need higher doses because they are less efficiently absorbed.

pinehurstcharlie · 04-15-2012, 12:28 PM

Quote:

Originally Posted by Shezian

Read through the thread roughly, and sorry am still confused which is the better one to use?

Sue

Back to the Nexium , I'm suppose to take it daily but if I watch what I eat I don;t take but sometimes every other day if I can. As I was finding out from bone scans that I"m looking at bone loss not to the point for medicine , I found out that nexium causes bone loss and the meds they want to give you for bone loss causes acid reflux. So my best approach is to cut back on nexium when i can as i think it is blocking too much to start with tht I need elsewhere in my body.

Idiopathic PN · 04-15-2012, 03:18 PM

Quote:

Originally Posted by mrsD

SAMe does not have any interactions that I know of.

The only warning it carries is for bipolar patients, who might get
hyped up on it and not realize. But even then it is a mild warning, not a big one.

Here is a long monograph:
http://www.umm.edu/altmed/articles/s...ine-000324.htm

I don't think it will have any negative effect on the gabapentin, and may in fact improve your cognition which is a common side effect of gabapentin.

It is really a great supplement and just a few months ago had the price decrease, at Costco's. I joined Costco in fact over a decade ago, just to buy it---since it was lower price there. All the money I saved payed for my membership several times over in fact back then.

There is a guarantee on NatureMade's website...if you don't like it you can return it (free shipping) for a full refund, with receipt and unused portion.

The drug interactions listed are the same as for serotonin increasing drugs. But since the SAMe is not increasing it so high like drugs do, the warning is basically a "cover your butt" warning. For people taking SSRIs or SNRIs, the warning is germain and should be followed however.

I didn't find SAMe much help for my PN, so I don't bring it up here often. But it is very good for joint and tendon issues.

I bought my SAM-e at the Commissary. Its NatureMade, 200mg, 24 pcs a pack at $9.99. I was looking for a 30-day package but I only saw the 24-piece package. I am a Sams member but not Costco. I compared the price online, it came out that the Commissary price is cheaper.

I wonder if the price at Costco is cheaper than the Commisssary's price. I should look for the cheapest quality supplements because the supplements we (PNers) are taking are for the long haul.

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