[mrsD]

Cymbalta and other SSRI type antidepressants, affect serotonin at the nerve synapse. It is believed that these drugs work in the brain to suppress the brain's interpretation of pain signals.

All drugs that affect serotonin have sweating issues.

[angel04]

Originally Posted by mrsD

Cymbalta and other SSRI type antidepressants, affect serotonin at the nerve synapse. It is believed that these drugs work in the brain to suppress the brain's interpretation of pain signals.

All drugs that affect serotonin have sweating issues.

Thank you its all a bit clearer now, do you know if there is anything else I can take that will have the same affect but allow me to start taking tramadol?

[aussiemom]

Did you, or are you still doing Chemo after your mastectomey? I'm going to start it Tues, and have read that can trigger PN, so may want to get with your surgeon.

[mrsD]

If you are going to start chemo.... I'd suggest acetyl carnitine NOW before you start, during and after to protect your mitochondria.

http://www.ncbi.nlm.nih.gov/pubmed/22271810

http://www.ncbi.nlm.nih.gov/pubmed/17696592

I believe you will need at least 2 grams a day, in divided doses.
Carnitine is not well absorbed, so breaking up the doses over the day may help get more into the bloodstream.

[Kitt]

Originally Posted by aussiemom

Did you, or are you still doing Chemo after your mastectomey? I'm going to start it Tues, and have read that can trigger PN, so may want to get with your surgeon.

I do believe it will depend on the type of chemo you have. Some are really awful for having PN like Vincristine or the like.

[angel04]

Originally Posted by Kitt

I do believe it will depend on the type of chemo you have. Some are really awful for having PN like Vincristine or the like.

Hi I've already had the chemo and radiotherapy and I was ok with it, had the usual nausea but thought it would be worse. What type of cancer do you have? one tip for you ask them if they put the anti-nausea drugs into your chemo drip, thats what helped me I believe and will make a big difference to you. The very best of Irish luck to you, let me know how you get on

[Kitt]

Originally Posted by angel04

Hi I've already had the chemo and radiotherapy and I was ok with it, had the usual nausea but thought it would be worse. What type of cancer do you have? one tip for you ask them if they put the anti-nausea drugs into your chemo drip, thats what helped me I believe and will make a big difference to you. The very best of Irish luck to you, let me know how you get on

Hi,

Sorry for the misunderstanding. I do not have cancer and never have had it or any type of chemo. I certainly hope I never have to deal with it. I do know a lot of people around my area dealing with cancer in one way or the other for the first and second time. Vincristine and the like are something a CMTer with CMT1A would never want to take.

I knew a guy, general population in my area, who had cancer and they gave him Vincristine. He did get numb, PN, etc. and had to get off of it. It was awful for him. He eventually died.

There are so very many kinds of chemo. Some people feel great, never lose their hair, etc. For others it can be brutal.

[Dr. Smith]

Originally Posted by angel04

I really do want to go back on tramadol and get off these but is there any other medication that numb the nerves in my head?

That's one of the questions your doctor should be able to help you with, as s/he's more familiar with your particular history, records, etc. Combinations of meds can be bad (interactions) or good, depending on which ones, why they're being prescribed, and individuals' responses.

Doc

[Steven N]

Originally Posted by angel04

Hi I've joined this forum as I feel lost and don't know who to talk to, my GP knows very little about this condition and I have loads of questions. I have found so many positive messages on this forum and am glad I joined. I had a mastectomy in August last year and had a lot of problems with haemotas and infections following that, until 6 weeks ago I had no idea I had PN. I live alone and have two budgies to talk to, a week ago I travelled home to Ireland to see my Mum and was delighted that the whole experience was enjoyable, even the flight which I was terrified of. I am on duloxetine, gabapentin and amitrylene, however I want to stop the duloxetine as I want to start on tramadol, but each time I try to stop and take tramadol my scalp starts to sweat and becomes dry and flaky I end up with a rash in my hair and on my forehead, its some type of fungai which, it seems, duloxetine controls. Does this sound mad ? or does anyone have something similar? If so I would love to hear from you and if someone can help with the scalp problem I would be so so happy to hear from you. I feel positive right now and hope I can be like all of you and stay positive:

I'm not qualified to give a medical opinion, but from my experience and my reading, it sounds like you may be suffering from the effects of gluten in your diet. Neuropathy is a symptom, and not an illness. If your doctor doesn't have a better explanation for the cause, I would work on eliminating gluten; it will get rid of many symptoms. I recommend Wm Davis' book, "Wheat Belly," about $15 from Amazon. It has served me better than years of medication and medical bills.

Best Wishes,
Steven

[Sallysblooms]

My Doctor likes that book. The book "Minding my Mitochondria" is SO good. Healing the nerves and mitochondria.