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Old 08-31-2006, 05:54 AM #1
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Default I'm sending Rose a big thank you--

--as once that page is finished, it will literally be a life-saver, and hopefully not subject to being "lost", as is the huge compliation of info she has at Braintalk 1. I'm not entirely sure, but I believe her initial B12 thread there went on for something like 660 posts or so. A very important document, and while hopefully it will become accessible again, it's important there will be a seperate place to access the info (like it is with JCC's Gluten File).

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Old 09-01-2006, 09:27 PM #2
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Default The Gluten File

O.K. I remembered this file from the other neuropathy website. It's Jcc (Cara's) website about gluten sensitivity and the huge file of info she has on it.
http://jccglutenfree.googlepages.com/

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Old 09-10-2006, 11:20 PM #3
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Default

I don't think I see the link for The Gluten File yet...so here it is.

Also direct links to these pages:

The Neurological Manifestations of Gluten Sensitivity

Peripheral Neuropathy

Diagnostic Testing

Gluten Sensitivity vs. Celiac Disease

At Risk Population for Gluten Sensitivity/Celiac Disease


oops...I guess I didn't advance to page 2 when reading this thread...I didn't see it...thanks Billye!
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Old 09-11-2006, 07:10 AM #4
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Lightbulb great!

Good for you, Rose...for putting your info on Google!

Here is a copy of a list I made in the past:

I have a new link HERE about medications as well:
http://neurotalk.psychcentral.com/thread161040.html
1) OTC--vitamins/nutrient interventions
Quote:
Known to help:

B12 at least 1mg (1000mcg) per day (methylcobalamin preferred) but some do better on 5mg.

Thiamine (B1) at least 200mg/day..but some here have used 500mg/day in divided doses. This is inexpensive and benign. Especially useful if you drink, used to drink or have alcoholism genes in the family tree. If you use diuretics for blood pressure, you deplete thiamine so supplements are a must then.

Omega-3 fatty acids... fish oil especially at least 2grm per day, and more if you choose. Help to maintain the myelin of the nerves and support the nerve membranes/action during transmission. Works in conjunction with B12.

Alpha Lipoic acid... this can be found now in the R- version, and can be used in lower doses because the R is more effective. Most ALA therapies use high dose-- and this can be expensive. ALA also can affect blood sugar--lowers it-- so be careful if you are a diabetic on medication.

Acetyl-l-carnitine is also useful...but large doses of a gram a day or more may be needed. This is expensive as well.

Inositol is newly being looked at specifically for diabetic neuropathies. Diabetics lose alot of this B-relative thru the urine for some unknown reason, and supplementing with it restores lost functions. You need at least 1gram a day--but this is inexpensive --if purchased from iherb in powder form-- mixes tastelessly into juice. D-chiro-inositol is being trialed as a drug to patent for this purpose, presently.

Support nutrients:

P5P--pyridoxal-5-phospate is the active form of B6 and helps with nerve issues and supports B12 metabolism-- 50mg/day typical

Folic acid or the new methylfolate-- Ditto 800mcg/day typical

Magnesium--- for those with poor diets who do not get this valuable mineral from foods-- and who are depleted by certain drugs like hormones, diuretics, some antibiotics and hormone replacement therapies. 200-300mg of elemental magnesium per day typical.

Ancillary supplements:
Chromium to improve carbohydrate metabolism/insulin actions max 200mcg/day

Zinc and selenium to enhance thyroid hormone T4 conversion in tissues.
Zinc=up to 30mg/day selenium max 200mcg/day Some drugs deplete zinc, esp ACE inhibitors used for blood pressure

Antioxidants to quench free radical damage to nerves/fatty tissue--
green tea/yerba mate/ grapeseed extract/ Vits A C and E, curcumin

Bcomplex.... in general the other B's have separate functions, so using them is a good idea. B2 for example activates conversion of pyridoxine in the body if you do not use P5P.
2) Drugs used:
Quote:
Drugs for PN...

AEDs (anti-seizure drugs)
Tegretol/Trileptal both drugs are cousins and similar in action
Dilantin (phenytoin)
Topamax --hard to tolerate
Zonegran
Lamictal
Neurontin/Lyrica
Keppra
Gabatril


Prescription Vitamin preparations

Mentax (the newest and best--- methylfolate, P5P, and methylcobalamin)
Folgard RX


Antidepressants

Elavil (amitriptyline)-- a tricyclic
Pamelor (nortriptyline)-- a tricyclic
Prozac, Lexapro, Celexa, Zoloft, Paxil --- SSRIs
Effexor, Cymbalta -- some norepinephrine reuptake actions
Desyrel (trazadone) mostly for sleep issues

Opiates
Oxycodone (Oxycontin,Percocet)
Morphine (Avinza, MsContin, Kadian)
Duragesic patches (fentanyl)
Vicodin, Lortab Norco (hydrocodone with tylenol)
Codeine (Tylenol with Codeine)
Methadone
Dilaudid (hydromorphone)

NonOpiates
Darvon/Darvocet
Talwin/Talacen
NSAIDs (Ibuprofen, naproxen, Celebrex, Indocin)
Tylenol
Ultram (tramadol)
AlkaSeltzer (with aspirin)

Anti-diabetic drugs for insulin resistance or type II diabetes

Metformin (Glucophage)
Actos
Avandia
Glypizide
Glyburide
Prandin

Benzodiazepines (AntiAnxiety/muscle relaxant)

Klonopin (clonazepam)
Xanax (alprazolam)
Ativan (lorazepam)
Valium (diazepam) Valium and Klonopin are the most commonly used for muscle issues/ and also have some anti-seizure effects

Topical agents

Lidoderm patches-- these are very nice if placed properly
Lidocaine ointment
Emla cream (now called LMX 5%)
compounded ointments with Ketamine/clonidine/ketoprofen/gabapentin etc
Biofreeze (this is very cooling, and also anti-inflammatory)
Capsacin cream (most people cannot tolerate the burning from this, but others like it)

Muscle relaxants (non benzo)

Flexeril (cyclobenzaprine)-- most commonly tried
Soma (carisoprol)-- abusable
Robaxin -- old timer not used much anymore
Norflex (orphenadrine)
Skelaxin-- very sedating, and often used for resistant patients who don't respond well
Baclofen (Lioresal)--mostly for spasticity issues

Dopamine agonists (for restless legs/movement disorder)

Mirapex
Sinemet
Requip

Misc:
Stadol nasal-- very abusable
levothyroxine--T4 (for thyroid replacement-- if low), liothyronine (T3)
antihistamines for skin burning (Benadryl/Claritin/Zyrtec/Atarax/Allegra) Benadryl and Claritin are OTC
Singulair (leukotriene B4 antagonist for allergic issues)
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Last edited by mrsD; 08-30-2012 at 12:40 PM. Reason: updating old broken link, adding new one
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Old 09-11-2006, 11:49 AM #5
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Default I FOUND IT! Eureka! The nerve/skin site! below....

http://telemedicine.org/stamford.htm At the left, table of contents, click on 'Anatomy of the Skin'. It is dense, rich and chock full of how nerves relate to other body functions...all of which dovetail into neuropathies completely.

Personal experience on my part is that it well, EXPLAINED A LOT! - j
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Old 04-17-2008, 10:31 AM #6
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Default

Quote:
Originally Posted by mrsd View Post
Good for you, Rose...for putting your info on Google!

I found the cached archive for the previous sticky on the "drugs used for PN"

http://216.239.51.104/search?q=cache...&ct=clnk&cd=21

Here is a copy of this list too:
1) OTC--vitamins/nutrient interventions


2) Drugs used:
Note: Zyrtec is now sold OTC as well. Walmart has it as does CVS. I don't know about any other drugstores/locations. Walmart it's a little over 19.00 for 30 tablets. They also have a generic but I've found from experience, after trying the generic that I experience break-through itching with the generic and I don't have that problem with actual Zyrtec. I take Zyrtec for idiopathic itching.

So it wasn't my imagination that Atarax lessened the burning in my feet! I was given Atarax for break-through itching and anxiety. I found, before I found other treatments, that Atarax often lessened my symptoms at night and also made me groggy so I could sleep.
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Old 06-29-2008, 10:35 AM #7
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Lightbulb Patches for pain relief

The subject of patches has just come up.

Here is a short explanation of what is available now as of 6-08
for pain relief:

Okay... this a good time to explain patches, I guess!

There are several types.

1) Fentanyl (Duragesic) RX ONLY--this is a very potent narcotic and effective but has alot of warnings with it to NOT use in people who are not already using high doses of another narcotic.
(the term is opiate naive). There can be severe side effects and even death if it is improperly prescribed and monitored.
But for severe pain...it is effective.
http://www.duragesic.com/duragesic/
These CANNOT be cut or severe results will occur including death.

2) Lidoderm patchesRX ONLY -- these contain lidocaine which is a numbing agent. They were designed specifically for post herpetic neuralgia, but they have been shown to work very well for other chronic pain issues. I started these right when they came out.. and really like them. They help me tremendously.
(placement can be tricky, and failure with them may reflect where they are placed).
Their website:
http://www.lidoderm.com/
These MAY be cut to fit any size placement.

3) Salonpas OTC-- These are over the counter pain patches with different formulas. I use the ones with methyl salicylate in them. They are more effective than BenGay or IcyHot patches which only have menthol in them.
Salonpas(R) Pain Relief Patches & Sprays for Powerful Pain Relief When and Where You Need It.
These MAY be cut to fit fingers and toes.

4) Flector--RX ONLY these are new in USA, and I am trying to get some. It looks like I will have to wait until September, since my doctor is leary of new things...
These have the NSAID diclofenac in them. I expect them to work like the Salonpas. However the Salonpas cost pennies each and Flector costs mega DOLLARS!
They have been in Europe for about 15 years, and have just been approved for "short term pain" here around January 08.
FLECTOR(R) Patch (diclofenac epolamine patch) 1.3% | Safety Info
These may be cut (but the doctor I talked to at their website says the FDA has not approved cutting them however, yet, but that may be in the future approved)


5) There is an antidepressant in patch form, called Emsam. RX ONLY
However, as of now, the company that makes it is not targeting it for pain. That might change in the future, as many drugs become commonly prescribed off label.
44 - File or directory not found.
This is an MAOinhibitor, and requires careful supervision.
These MAY NOT be cut.

I personally like the patch idea. I use both Salonpas and Lidoderm with great success. (Lidoderms are expensive if your insurance does not cover them). Salonpas are extremely INexpensive.

Edit to add: as of Oct 2016 there are two new topical patch types that are OTC now. Salonpas has introduced a stronger patch with ingredients more like their arthritis one.. but still called "original". They are available at WalMart now in a 60 patch box. But Costco still does not have them. The other small ones are no longer in stores but some Ebay venders are still selling them. Read the ingredients on the box to see if you are using the old original or the new product (which has 10% methylsalicylate in it)

Aspercreme is now offering a 4% patch (this is the same strength as the lotion with Lidocaine the offer. The RX form of Lidocaine patches are 5% in comparison and much more expensive than the new Aspercreme 4% ones.
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Old 11-21-2008, 08:54 PM #8
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Default Just came across a new diagnostics web site....

It appears to ba a primer for Family Practice docs, so the viewpoint is in doc-speak.

If you go to the bottom of the page and back to the index, it too is interesting.

http://www.aan.com:80/familypractice/html/chp3.htm

- j
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Old 12-20-2008, 09:29 AM #9
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Default Skin Biopsy Article

It's pretty thorough.

http://www.bmj.com/cgi/content/full/334/7604/1159

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Old 01-22-2009, 02:29 PM #10
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Default

This is interesting; skin biopsies of healthy skin and skin with peripheral neuropathy. Imo this link wasn't posted yet, but I hope I searched well

http://www.nature.com/ncpneuro/journ...neuro0630.html
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