My Navy buddy, who said he got laid out on the floor, even on a small dose, never did say what his "small" dose was. I just figured that 90 - 100mg pills with upping the dose every other day would run you. When you get to your second dose of 100mg, make sure you've spaced it out in the day. When you get to 4 pills & more, daily, probably work your way around the "route". My Nero started me on 4-100mg daily & that sure wasn't enough. On that first prescription of 120 caps, I moved up to 600mg daily & then 900mg daily, without the desired effect on my "folded sock" behind the toes. I'm at 600x3 daily now & I really could use a 4th dose, and probably 300mg would do it. Half another pill. (600's are scored hard oval pills). I really don't want to give you any personal recommendations if you need to go beyond 300x3, but by that time, jumping 300mg a day shouldn't knock you on your butt, after your body gets used to the stuff. You might get a bit light headed for a short time, but not too bad.