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Old 11-14-2012, 06:13 PM #3
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
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Lightbulb

I think you will need a specialist to evaluate these results.

Folic acid is in American food as an enrichment product... in fact quite a bit. But it is NOT the methylated form Methylfolate.
If you cannot methylate it? With the error? That creates a
problem.

If you take 1000mcg of methylB12...you only absorb about 10mcg of it. That is only about twice as much as from food.
I'll have to look this over. But I think a specialist is needed
and you should consult one who understands methylation chemistry.

I also think..given the recent revelations about compounding pharmacies and epidural drugs made there....you should find out what drugs were used on the cervical epidurals you had.
It is possible there is a connection there. Protein in the CSF?
I'd really check this out if I were you. I personally believe this problem with "cheap" substitutes for brand name SoluMedrol,
were being made for many years, and could also be contaminated. The media has not yet released this risk, but I do think it exists, since the company was warned in the early 2000's about cleanliness etc.

Did you ever have a homocysteine test? was it elevated or normal?
I see your MTHFR is +/- which is a mixed mutation. This is not as serious as a +/+... full mutation. People with +/+ mutation here cannot methylate B12 or folic acid properly. Partial mutation means only some methylation. Methylation means moving a -CH3 group from SAMe to the desired location to activate it. People with MTHFR mutations cannot use B12 or folic acid properly.(and would need the methylcobalamin and methylfolate instead of other forms for these vitamins.)

I think at this point you should only pay attention to +/+ presence of mutation (shown in red)

The neurotransmitters in the the brain are methylated and activated by -CH3 group via enzymes. With the mutation showing +/+...you have a decreased capacity for it.

Some of the comments refer to the autistic community because many of them have methylation problems. Often methylB12 is used as a high dose injection for them.

To read more about psychiatric and autistic methylation issues,
consult Pfeiffer Institute online.
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Last edited by mrsD; 11-14-2012 at 07:18 PM.
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