Thread Tools Display Modes
Prev Previous Post   Next Post Next
Old 11-28-2012, 07:14 AM #10
glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
glenntaj glenntaj is offline
Magnate
 
Join Date: Aug 2006
Location: Queens, NY
Posts: 2,857
15 yr Member
Default Yes, this type of neuropathy onset--

--is rare, but not unheard of. It certainly happened to me.

Generally, it is considered a variant of Guillain Barre syndrome, and often suspected to be caused by a similar process--autoimmune molecular mimicry. The body reacts to some pathogen with an immune response, and may often succeed in destroying the pathogen, but the pathogen turns out to have a very similar molecular configuration to some component of peripheral nerve (much of the body's immune response is mediated by molecular shape), and the now activated immune system attacks anything with a similar configuration as it cannot distinguish the nerve from the original pathogen.

In classic Guillain Barre, the attack is directed at components of the myelin sheathing of the larger nerves, so people get motor, sensory and often autonomic symptoms. In the small fiber variant, the attack is against the components of the nerve itself, as small fibers have no such sheathing; since small fibers are sensory and autonomic, there are typically no motor symptoms (mine were all sensory). Also, since the attack was to nerves too small to be measured by standard nerve conduction studies, it took skin biopsy to confirm there was damage to the smaller nerves.

The Washington University Neuromuscular website has good info on this:

http://neuromuscular.wustl.edu/sensory-small.html

http://neuromuscular.wustl.edu/senso...tml#idiopathic

http://neuromuscular.wustl.edu/antibody/gbs.htm#sens
glenntaj is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
heb1212 (01-16-2013), hopeful (11-28-2012), Spectrum (11-28-2012)
 


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Newly Diagnosed - Small Fiber/Large Fiber Neuropathy! Please Help! JoshuaY46012 Peripheral Neuropathy 17 11-12-2019 03:55 AM
Small Fiber, Large Fiber & Autonomic Neuropathy Loves Pappilions Peripheral Neuropathy 9 06-01-2011 09:02 AM
Small fiber neuropathy Karenswails Peripheral Neuropathy 30 03-29-2011 01:33 PM
Small Fiber Neuropathy (or Length-Dependent Neuropathy) plgerrard PN Tips, Resources, Supplements & Other Treatments 1 05-09-2010 06:56 AM
Small fiber Neuropathy dovepainter Peripheral Neuropathy 3 12-21-2007 04:13 PM


All times are GMT -5. The time now is 12:29 AM.


Powered by vBulletin • Copyright ©2000 - 2025, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise (Lite) - vBulletin Mods & Addons Copyright © 2025 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.