I couldn't tolerate Neurontin. In my case it caused depression so bad that I was near suicidal.I have been on Amitriptyline for several years now and it helps with both my neuropathy symptoms and sleep.

Sorry to kind of go off course on this. I'm on Nortriptyline and if I go above 40mg a day, I get quite anxious and tremors. I also feel like dead meat in the AM above 40mg, too. I still have the tremors, but not nearly so bad. Lost a few pounds, too. What's your dosage and what kind of side effects do you experience? I know everyone is different, but I am thinking of asking to switch to Amitriptyline, hoping to be able to up my dosage a bit without the anxiety.

I worked my way up to 40 mg. I started at 10 mg and initially experienced some dizziness, but that quickly passed. I've been on 40 mg for about 2 years. If I'm having a hard time falling asleep I will sometimes take an additional 10mg. Other than the initial dizziness, I haven't really experienced any side effects. If your are experiencing AM fatigue, you might want to try taking it earlier in the evening.

I had a hard time falling asleep at under 40mg. I already take it 3 hours before bedtime, but I could still pry myself from the pillow in the AM. The most bothersome is the jitteriness (anxiety) at 50mg and the shakiness (tremors). It's really embarrassing to have a sales clerk help me dig the change out of my hand. I wonder if they think I was on a bender the night before. LOL. Being in public makes me worry that I WILL have the shakes, too. The shakiness is worse in my non-dominant left hand, but the shakes still can be bothersome even at home (try holding a glass of water). When I see my Neuro next month I'll probably ask to give the Amitriptyline a try.

Did I mention that when it's hot & humid the sweat also pours out from under my baseball cap? That's still something I can deal with, though. I had lesser tremors before I quit smoking 6 years ago (Chantix). The PN came just over 2 years ago.