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Old 06-08-2013, 07:45 AM #1
glenntaj glenntaj is offline
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glenntaj glenntaj is offline
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Default You probably need--

--to repeat those abnormal tests from some years ago; they point to an autoimmune possibility for the symptoms, which may have been dormant until recently.

In particular, you should get an immunofixation electrophoresis of serum and urine to check for rogue polycolonal and monoclonal proteins and cryoglobulins, which are associated with neuropathy through antibody cross reaction to nerve antigens. Moreover, there are now assays for antibodies specific to components of peripheral nerve that were not available 19 years ago. And an overall physical exam would probably be a good idea to eliminate something new.

Take a look at:

www.lizajane.org (particularly the immune section)

http://www.questdiagnostics.com/test...ripheralNeurop
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Old 06-11-2013, 02:58 AM #2
Koi13 Koi13 is offline
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Default

Quote:
Originally Posted by glenntaj View Post
--to repeat those abnormal tests from some years ago; they point to an autoimmune possibility for the symptoms, which may have been dormant until recently.

In particular, you should get an immunofixation electrophoresis of serum and urine to check for rogue polycolonal and monoclonal proteins and cryoglobulins, which are associated with neuropathy through antibody cross reaction to nerve antigens. Moreover, there are now assays for antibodies specific to components of peripheral nerve that were not available 19 years ago. And an overall physical exam would probably be a good idea to eliminate something new.

Take a look at:

www.lizajane.org (particularly the immune section)

http://www.questdiagnostics.com/test...ripheralNeurop

Are most of those tests through that Quest Lab a blood test or a spinal tap fluid test? Particularly the autoantibodies to peripheral nerve antigens.
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Old 06-11-2013, 05:59 AM #3
glenntaj glenntaj is offline
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Default Everything --

--listed on that lab listing is serum (blood) test.

Most of those antibodies could also be looked for in a spinal tap, but most of the time a spinal tap would be done to look for other proteins more characteristic of problems with breakdown of myelin in the central nervous system, rather than the peripheral. (Brain and spinal cord myelin has a different lipid structure than that of peripheral nerve myelin.)
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