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09-30-2013, 05:47 AM
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#14 | |||
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Wisest Elder Ever
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The problem with NSAIDs for many people, is that they cause
bleeding in the GI tract. They also promote heart damage due to their blocking of Cox-1 and Cox-2 cytokines. Cox-2 cytokines have a member called prostacyclin, which is secreted by the kidney and it is responsible for dilating blood vessels. Block this cytokine, and coronary vessels are affected --constricted---and prone to heart attacks. In studies the least likely NSAID to affect this cytokine was naproxen. But they ALL do to some extent. It is a pretty severe risk IMO for chronic use for depression. My neighbor had an almost fatal bleed from naproxen... she was in intensive care for 13 days.
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