Hi Marie,

I do not take amitriptyline for depression; this dose (10 mg) is allegedly too low for that anyway (I think any change in my mood is due simply to getting better/more sleep).

How to Take Elavil (Amitriptyline) for Chronic Back Pain

I couldn't say for sure that it's helping any neuropathic pain because 1.) I'm asleep while it's working, and 2.) my burning pain from PN is alleviated entirely by taking RLA (100 mg) daily.

As I mentioned in post #8 ADDENDUM, I tolerate this dose of amitriptyline very well—with no side effects whatsoever.

If you haven't discussed it with your doctors already, you might ask/suggest them about switching from Lyrica (pregabalin) & Elavil (amitriptyline) to gabapentin & nortriptyline.

Study finds that the combination gabapentin plus nortriptyline reduces neuropathic pain more than either drug alone

I believe (not certain) that this may be the referenced study:

Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial.
Nortriptyline is a 2nd generation tricyclic antidepressant, while amitriptyline is 1st generation. As such, nortriptyline is generally better tolerated with a lower side effect profile.

I looked briefly for any similar study using Lyrica and amitriptyline, but did not find any (doesn't mean there isn't one—I just didn't find any).

Hope this helps, & Best Wishes,

Doc