Does anyone know how to interpret NMR LipoProfile results? I'm trying to sift through mine to understand what they're trying to tell me.

I had some lipid panels done in 2013 and 2014 and learned which areas I needed to adddress and how to address them. Do you have a few specifics.

Doctor in now way had time to go over these tests and help me.

Because of my day job I know a fair bit about NMR and lipids - I would be happy to see what I can make of your results.

I would like to see what Kiwi has to say too.

But this might help understand NMR lipid tests too:

https://www.nhfcpepicentre.org/Porta...id_profile.pdf

There are some nice graphics on that site.

I don't know if I posted about Dr. Sinatra's position on statins and heart health in general, but I so much respect and follow his info. I don't take statins and I'm pretty sure never would. On my 2014 lipid panel, my MD tested COQ10 and I see it's a little lower than is optimal, so I've upped my COQ10 regardless and take 200mg at least daily. Some days take 300mg. He talks about COQ10 in his comments. I didn't read thru this whole thread so maybe it was mentioned, but worth mentioning again can't hurt.

Statin Drugs: What They Do & Who Should Take Them | Dr. Sinatra

Thanks everyone. I'll post below what I think are the relevant results out of 31 reported ones. If I'm missing any that would be helpful, please let me know. They flag three results as "high," and I'm showing those.

What I'm basically trying to understand is the real cardiac risk of my supposedly elevated LDL related to particle size. I know the small dense ones are the bad ones. From another source, I learned this about Ldl particle size:

Pattern A - Larger, less dense 20.6 - 22
Pattern B - Small, dense 19.0 - 20.5

Ldl-P 1446 (high)
Ldl-C 157 (high)
Ldl Size 21.1
Ldl Size Percentile 73.5
Small Ldl-P 463 (reference range <=527)
Large Ldl Particle Number 819

Triglycerides 52
Hdl-C 66
Hdl-P (Total) 27.6
Cholesterol, Total 233 (High)


Based on what I'm reading into this, I'm not in too bad shape despite a high Ldl-P. My Ldl particle size is averaging in the Pattern A range, and my Ldl numbers significantly outnumber my small Ldl numbers.

Am I thinking about this right? I have m doc appt on Wednesday, and I just want to be a little educated about this before I hear what she has to say.

Thanks so much!

Janie

The particle count is the biggest driver for atherosclerosis. You are an ApoE4, correct?

Dr. Tara Dall discusses LDL, LDL Cholesterol (LDL-C) & LDL Particles (LDL-P) - YouTube

Dr. Tara Dahl used to practice in Wisconsin and is a lipidologist.

No, thank goodness. e3/e3

So you're saying the particle size doesn't matter? It's the total count?

Watching the video now...

Janieg, I think that mrsD and madisongrrl have provided great comments and links.

I don't know how much background you know but this might help you when you see your doctor:

Lipoproteins are particles which differ in their density - eg, LDL is Low Density Lipoprotein and HDL is High Density Lipoprotein. Each class and subclass of lipoproteins contains different proteins and different proportions of lipids, including cholesterol.

There is reasonable evidence that the amount of cholesterol in LDL ("Ldl-c" in your results) is a risk factor for cardiovascular disease. However, it has become clear that the number of LDL particles ("Ldl-p" in your results) is also important.

This is something which Dr J D Otvos and his colleagues have worked on. They developed a clever NMR method to calculate the number of LDL particles. Dr Otvos is a respected scientist with 134 papers in PubMed.

He and his colleagues looked at subjects in the Framingham Offspring Study, which is a long-term (it started in 1971) study looking at risk factors for cardiovascular disease. They found that the probability of survival was highest in people with low LDL-P and low LDL-C and lowest in people with high LDL-P. The paper is here LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management. - PubMed - NCBI - the PDF version of it is easiest to read.

Your LDL-P and LDL-C levels look high to me.

My approach to this (my LDL-C levels are fine so this is prophylactic) is to try to eat in a healthy way - lots of fresh vegetables, fish, eggs, meat in moderation, etc and minimal intake of food/drink with added sugar and foods with highly processed carbohydrates.

Your doctor should be able to advise you about this and I think that it is highly likely that mrsD and madisongrrl can be helpful as well.