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Niacin is my enemy

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Old 04-07-2014, 10:52 AM #1
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I believe that :

Quote:
rs1801133 is a SNP that is relatively common and has been studied for (relatively) a long time. Also known as C677T, Ala222Val, and A222V, it encodes a variant in the MTHFR gene, which encodes an enzyme involved in folate metabolism.

Homozygous rs1801133(T;T) individuals have ~30% of the expected MTHFR enzyme activity, and rs1801133(C;T) heterozygotes have ~65% activity, compared to the most common genotype, rs1801133(C;C).
from http://snpedia.com/index.php/Rs1801133
This link has a more complete explanation.

Your TT means you do not methylate properly so should be using methylB12 and methylfolate.
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beatle (04-07-2014)
Old 04-07-2014, 11:08 AM #2
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So glad you have come out of that hellish spiral.

I'm hopeful it was indeed the niacin so that a similar flare can be avoided in future.
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Stacy2012 (04-07-2014)
Old 04-07-2014, 12:25 PM #3
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I am not really out of it. I am still on the couch all night, sleep 2 hours then wake and must put in water to bring down swell and pain and its a cycle.

Day time is a little better but I still cant walk much, if I am on them longer than 15 minutes, big flare. Not leaving the house much, I tried walmart with hubby yesterday and used the electric chair and they still flared.

Life is pretty miserable right now, and while I have an app. with neuro, I am not very hopeful.
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Old 04-07-2014, 12:30 PM #4
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Quote:
Originally Posted by Stacy2012 View Post
I am not really out of it. I am still on the couch all night, sleep 2 hours then wake and must put in water to bring down swell and pain and its a cycle.

Day time is a little better but I still cant walk much, if I am on them longer than 15 minutes, big flare. Not leaving the house much, I tried walmart with hubby yesterday and used the electric chair and they still flared.

Life is pretty miserable right now, and while I have an app. with neuro, I am not very hopeful.
I am sorry to hear this. I guess we all hoped that you were coming out of the tunnel. The neuro may be able to help you, if not with a cure at least with some effective medication so that you can get your life back and your feet out of the water. That scares me as I do not think it is good for you long term.

Hope this turns around soon
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Old 04-07-2014, 12:53 PM #5
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No, it is not good. I guess a drug induced coma is better. :/
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Old 04-07-2014, 04:02 PM #6
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Hi Stacy,
Where did you hear about the coma. Where you originally diagnosed with RSD? That is what they generally place patients in the coma for. Were you told what drug they use for the coma?
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Old 04-07-2014, 04:10 PM #7
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Hopeful, I just meant that for me, pain drugs always make me feel like that. I do not hold out high hope for my cure to come in the form of pain medication, it always seems to cause me more problems. Therefore, I do not have a lot of hope, since drugs are the answer, not cure.
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