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Old 01-16-2015, 05:09 PM #1
aneczka aneczka is offline
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Default Genetic and methylation profile
Just received preliminary results of my genetic screening. My methylation profile shows some mutations, actually a lot of them. Two homozygous, which are supposed to be more serious, and a lot of heterozygous. Can anyone help with analysing them? The information I received is a bit overwhelming, since it is all new to me. A quick, superficial read suggests I may have issues with vitamines D3, B12 and methylfolate.
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Old 01-16-2015, 09:46 PM #2
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Originally Posted by aneczka View Post
Just received preliminary results of my genetic screening. My methylation profile shows some mutations, actually a lot of them. Two homozygous, which are supposed to be more serious, and a lot of heterozygous. Can anyone help with analysing them? The information I received is a bit overwhelming, since it is all new to me. A quick, superficial read suggests I may have issues with vitamines D3, B12 and methylfolate.
One really good podcast is by a group of functional medicine doctors at The Center for Bio-individualized Medicine. You can find it on iTunes or can steam it from their website. They have lots of information on reading and interpreting your 23andme genetic profile; they have talked extensively about methylation. You could also goggle methylation on iTunes and see if other podcasts. Good luck.
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Old 01-17-2015, 04:20 AM #3
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So you will have to add methylfolate to your supplements
And raise your B12 to 5 mg a day at least.
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Old 01-17-2015, 08:53 AM #4
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Exactly, methylfolate was what I am thinking of.
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Old 01-17-2015, 08:57 AM #5
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Interestingly enough, it also shows a mutation which makes me vulnerable to celiac disease/ gluten sensitivity, and also some vitamine D absorption issues. I'll get them both tested.
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Old 01-17-2015, 09:08 AM #6
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Good thing you got the testing... now you can work around the mutations perhaps and regain some lost functions.

If you have Celiac and don't know it, you could be malabsorbing many other nutrients. So going gluten free may be a good idea, too.
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Old 01-17-2015, 09:11 AM #7
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Been doing that already, but not very religiously. Now I have a reason to be systematic about it.
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Old 01-17-2015, 09:17 AM #8
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That spells no more eating out so much Which is not a good news, because cooking with two bad hands is a pain in the .. hands. Can anyone recommend a good cooking book for going gluten-free?
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Old 01-27-2015, 05:54 PM #9
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mrsD, how much methylfolate would you take for every, say, 1000 mg of methylcobalamin? Would you take it with food? Got it today, but not sure what dosage makes sense.
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Old 01-27-2015, 07:07 PM #10
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800mcg a day of the methylfolate to start. There are no food restrictions I know of for it.

The methylB12 requires empty stomach and no food after for about an hour.

And this explains your gene in more detail:
http://ghr.nlm.nih.gov/gene/SMN1
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