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#1 | ||
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Magnate
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--there may be both inflammatory and non-inflammatory etiologies that may or may not show "standard" inflammatory markers. Particularly if there is an autoimmune attack by antibodies specific to antigens on small fiber nerve, this may not show up on the usual inflammatory tests as there may not be the same kind of lymphocytic infiltrates usually associated with measures of inflammatory markers (the damage may be caused by antibodies not only hard to measure but very specific to the individual).
Still, in many small fiber syndromes now designated "idiopathic", autoimmune processes are suspected. These may just be as of yet unPROVEN. It is important to note that most of the antibodies to specific peripheral nerve antigens--the type Dr. Norman Latov listed in his Quest diagnostic advisory paper--have only been discovered/recognized over the last thirty years or so. Last edited by glenntaj; 03-17-2015 at 05:01 AM. |
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"Thanks for this!" says: | Joe Duffer (03-17-2015), Sky22guy (03-18-2015) |
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#2 | ||
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Member
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Quote:
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"Thanks for this!" says: | Joe Duffer (03-17-2015) |
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#3 | ||
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Joanna I have almost the exact same overarching question as you do. Unlike you I can't tolerate Gaberpentin even at the lowest dose - nor Amitriptyline or Cymbalta so far - although I did manage Amitriptyline for over 3 years before the heart palpitations got the better of me. As I think we've discussed I'm having my skin biopsy done tomorrow by my GP - two punches on each leg. I've had a lumbar puncture, nerve conduction tests (no heat one as the neurophysio said that this isn't done in our hospital as it the equipment was too expensive), serum blood tests to see if this is immune mediated neuropathy and MRI of brain and neck. Nothing has come up so far. The only thing I always have is a high to elevated ESR/ Sed rate - which they say does relate to my autoimmunity but isn't specific enough to help establish more than this. I understand how sad all this is making you. I'm in an abject state of terror just now about my life and where it's all going - but just now the nerve pain in legs and arms is the least of the terror I think as things have mostly gone numb. I see my rheumatologist on Thursday but he is a fence sitter and defers to others including the neurologist. All I can say is that any result that shows up something has to be progress for either of us and I think we both have to keep pushing hard for them to get beyond the term idiopathic and start looking for proper solutions which might set our defective immune systems back on the right track. That's where I'm pinning my hope anyway. Mat x
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If you get lemons, make lemonade Sjögren’s, Hashimoto’s and Systemic Sclerosis with Raynaud’s, Erythromelagia and small fibre polyneuropathy, GI problems top to tail, degenerative disc disease and possible additional autoimmune diseases |
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#4 | ||
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What autoimmunities were you tested in the past for?
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#5 | ||
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Hi neuroproblem,
I am diagnosed with an autoimmune called ankylosng spondylitis (AS), it is a rheumatic disease. I have had this since 2001. The diagnosis is by MRI scans and genetic test for a particular HLA gene type. I also have psoriasis now and again and this has been popping up since the nerve problem commenced. I also suffer from uveitis which is an autoimmune problem afecting the eye. This comes with the AS. The tests I have had for immunity are CRP and ESR which I understand checks inflammation levels in the blood. These arent particularly high so my GP would send me away based on this alone. I have had tests to check thyroid, liver function etc. All the tests for B12, Vit D etc and diabetes. This is it in terms of blood tests or autoimmunity. |
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