Originally Posted by mrsD

The typical cancer triggers are lung cancer and some bone marrow ones. For females, ovarian is often tested for.



If your avatar is indicative of your age, I'd say it would be a rare thing to have for you. Not impossible, but not one of the first things to look for.



I think you should get the DNA test for MTHFR mutations.

This is more common and up to 30% of people can have it.

Poor methylation means B12 and folic acid are not activated in the body, so nerves suffer. Poor B12 functions are often mistaken for MS in the beginning of diagnosis.



Next most common is gluten intolerance.

Also exposures to vaccines, and certain food intolerances like gluten intolerance. Some people with gluten intolerance show MS like nerve symptoms.



Exposure to certain antibiotics in the past -- fluoroquinolones and Flagyl/Tinadmax also cause nerve damage.



Look at whatever you are doing when symptoms occurred. And try to change your lifestyle away from that. If it is overuse exercise, minimize that factor. If it is dietary, remove suspected intolerances with an elimination diet. Avoid exposures to chemicals. Avoid alcohol and smoking... smoking contains many toxins and also in males affects the circulation. (peripheral artery disease called PAD)



Look to the more common and obvious... the paraneoplastic area is one to look at last.

Originally Posted by Susanne C.

Would walking relieve the symptoms as well as running does? Running may be overdoing it. I have a sensory motor neuropathy that is pretty advanced but walking on soft trails does relieve some of the pain. Are you running on a hard surface?
It is very common for neuropathy symptoms to get worse in the evening.
Also, about caffeine, I find that it helps me rather than hurts but everyone is different.