I'm just starting this thread as a place to post things related to the ongoing research showing an association between gene mutations in the Nav1.7, 1.8, and 1.9 sodium channels and neuropathy. The second article below is less technical and quite interesting.


16 May 2014

Third Sodium Channel Implicated in Painful Small-Fiber Neuropathy
Mutations in Nav1.9 render pain neurons hyperexcitable

http://www.painresearchforum.org/new...ber-neuropathy


October 29, 2014

The Role of Sodium Channels in Painful Neuropathies

http://www.neurologyadvisor.com/targ...rticle/380020/

"This emphasizes the importance of the research on Nav1.7, Nav1.8, and most recently Nav1.9. These channels seem to be the ones that are specific to nerve pain. Pharmaceutical companies are actively working on drugs for Nav1.7 and Nav1.8 and will probably begin to include Nav1.9, now that it has also been linked to human pain. Finding drugs that selectively block just these channels could be the holy grail of neuropathic pain treatment."



September 20, 2012

Gain-of-function Nav1.8 mutations in painful neuropathy - Faber

http://www.pnas.org/content/109/47/19444.full



_____________________________