You might need P5P ...the activated kind. Maybe you are not converting B6 (found in typical supplements) to the P5P for the body!

This is the one I use:
http://www.iherb.com/Now-Foods-P-5-P...blets/740?at=0

P5P is the one included in the combo RX product for neuropathy called Metanx. I've used this active form for over 10 yrs now!

There is a condition called pyroluria. This is an inherited defect in the manufacture of heme in the liver. Basically it is not a "disease" in itself, but the defective by product kryptopyrrole, complexes B6 and zinc out of the body. This is tested using a urine specimen, sent to special labs. (most conventional doctors are not trained in this at all...but in Europe it is pretty well known).
Low B6 serum levels result, as well as low zinc.
Here is an article about that:
http://www.drkaslow.com/html/pyroluria.html

jccgf a member here (and longtime friend of mine) had her daughter tested for this and it came back positive. Supplements fixed her-- she went to a DAN doctor (Defeat Autism Now) who also did this treatment in addition to his other autism patients. jccgf is very helpful, don't hesitate to PM her if you need to!