Symptoms of motor neuropathy can cause twitching and also muscle weakness & muscle wasting. I have not found any online source that includes it as a symptom of SFN.

I am going to a neuropathy specialist on 9/8 and I have included this in my list of questions. I will get back to you guys with whatever I find out.

I've read that SFN can sometimes progress to include large fibers and when large fibers are involved than there's weakness and other issues.

Anyone else in your family have similar symptoms? Have you had DNA blood testing thru Athena Diagnostics? Very expensive. Thank you.

it depends on what is causing the SFN, if it something like diabetes, or autoimmune it will definitely progress.
twitching is pretty common for PN, ive noticed that my twitching has increased and also the duration as well. My myclonic and hypnic jerks made other parts of my body jerked, such as my jaw randomly closes, or both my legs muscle contract and it makes them jump/

And that is where things are stuck. I've got lots of test pointing to auto immune but just pointing. I did find out that I am indeed dealing with myositis. I'm not diabetic however my neuro did a Glutamic Acd Decarb Ab blood test and I had a high titer of .40 anything higher than .02 is considered high. So much going on and no clear picture. Doctors like clear.

That may be in the near future!

BTW THANKS everyone for replying. I'm on my phone and my eyes are a mess so I'm not sure if I'm replying correctly.

I asked my neurologist if my twitching meant that I had motor nerve involvement now in addition to sensory and autonomic SFN. She said, "not necessarily; twitches can be from lots of things." My nerve conduction velocity was normal but the EMG showed chronic reinnervation, which she explained was nerve damage followed by "sprouting" of fibers from nearby nerves to compensate for the deficit. Later she mentioned that there are just a limited number of muscles and nerves that are large enough and close enough to the skin for testing, and that there could be motor nerve damage in other inaccessible areas. So, a little more information but not really a definitive answer to the question.

Thanks for the follow-up. Your right though - that information doesn't really clear anything up. A lot of people seem to have twitching and cramping along with SFN. In my case, it was the first symptom. Taking gabapentin controlled it, and now it has mostly stopped. Not sure what would happen if I quit the gabapentin though. I do know the pain increases significantly if I miss a dose, but not sure about the twitching

Muscle twitching
 

This May I had a terrible fall & broke both tibula & fibular bones in my right shin. This fall has changed my life in so many ways. In result of this fall, not only have I was been "blessed" (for lack of a better word) with neuropathy & these muscle twitching episodes. They are the most annoying things, as all of you know. Luckily, I started taking a supplement loaded with B vitamins. On top of taking these supplements I also get B-12 shots regularly. In the past several days or so I have noticed that the twitching has more or less subsided. I'm not sure if the supplements had anything to do with it or not. I videoed my hands working up a storm when I was on my computer, so when I saw the Neurologist he told me I those were tremors. Lucky me. First neuropathy now this. Well like I said they have subsided quite a bit. Has anybody tried taking B vitamins for this?

Hi Ragtop262. As you know twitching was my 1st symptom too. I stopped my sleeping meds 2 nights ago and realized my middle of the night twitching had pretty much stopped. I did get a pre-twitching feeling one night but I got up and stretched and it was gone. It's only been 2 nights and I know I must wait longer before I get excited. I'm thinking the gabapentin has controlled it. I don't know how much it helps my burning and would love to stop the drug but I'm not ready to face the possible consequences.