Thank you for the quick reply MrsD. She hasn't had any numbness, more pins and needles, burning, stinging, ache and painful stabbing. But once the symptoms went down they weren't replaced by a feeling of numbness. We also haven't gotten the B12 levels back (only got a note saying they were "normal" and as we all know that doesn't mean much unfortunately). So when we get those numbers I might increase to a higher B12 dose. In 2011 she had a B12 level of 250, so it might be more or less than that at the moment. But I doubt it's over 400 - the doctos have told her that she has issues absorbing B12. I haven't yet looked at Folate/Folic Acid. I want to get the B12 levels from the blood work before continuing with more supplements.

As for Lyrica resistance - it's not impossible. But since we have been ramping up the dosage about 25mg every three days I would think the resistance wouldn't be an issue yet. She's also at a relatively low level at the moment. Nour neuro says we should aim for 200mg (so thats about one more week of dosage uppings) and see how that works.

Tomorrow my wife will hopefully have a phone call with the neuro and discuss this unfortunate new development.

On a side note I'm a bit scared of introducing new supplements because I'm afraid it will cause more issues with the NP. Is this an ungrounded fear? I'm mostly thinking of Folate, ALC, Q10, Alpha Lipoic Acid and Benfotiamine as these are a bit more rare supplements here in Sweden so there's not much "official guidance".