Here is an article about B6 supplements and toxicity.

http://www.ncbi.nlm.nih.gov/pubmed/16320661

Reports like this remain rare.... one has to wonder if these 2 patients had some sort of genetic sensitivity to B6? Or poor kidney functions.

One doesn't really need mega doses of B6 anyway.

Also... pyridoxine is not the active form either. Pyridoxal 5 phosphate is the active form. This form is typically not found in vitamin complexes... it has only been very recently added to some new formulas in the past couple of years. Some people may just not be activating the B6 and it is accumulating in the body as a result.

I have yet to see these anecdotal reports give serum levels for the B6.

But thanks for the reminder with this link. Everyone IS different and has different chemistries.

B6 is the one form of Vitamin B that seems to actually make my neuropathy pain worse. The others all seem to help with the pain.

Yes, very low B6 will cause neuropathy too.

As will very high levels for long periods of time.

There was a time in the US that 500mg a day to 1000mg a day of B6 was used to treat PMS in women!

That is when the high levels were discovered. The symptoms though of the toxic levels are different than the typical PN types too, in some ways.

I had been taking a P5P supplement that I got from the neurologist. It was only 50 mg. However, I was becoming alarmed because my leg muscles have been feeling very weird and I was starting to have trouble walking. I stopped taking the P5P and I am noticing improvement.