I've had muscle twitching in my legs, mainly calves for over 15 years non stop. I had an 3 EMG's over 12 years ago all normal. These EMG's were all after I was twitching for maybe 2 or 3 years. Was diagnosed with benign fasciculation syndrome. The last EMG was done at John Hopkins and they said it was not a large fiber neuropathy because EMG was normal but possible small fiber or distal myopathy but I never went back for anymore test's, I just lived my life normal for the past 15 years since it knew is wasn't going to kill me.

Fast forward to June 2015 when I decided to have my left knee replaced because it was really bad from all the sports injuries I had over the years. By the way I'm 64 and was in half decent shape, 6'2 weight around 195, so I'm where I should be weight wise I think. Anyhow...I noticed back around July Aug while I'm trying to recover from this knee replacement my legs felt heavy, thought it was just the lack of exercise and the surgery and pain pills I was taking. My legs fascis started getting worse, especially my good leg, the one that was not operated on. Getting fascis in the shin, down around ankles, calves are twitching more than normal. I've been using A cane to walk because the knee just does not feel strong and I'm having a hard time rehabilitating it. I just felt like I wasn't gaining so I went to GP and she said it looks like I'm losing muscle bulk in good leg calf muscle and she sent me to Nero. Had one visit and thinks I have what he described as a peripheral polyneuropathy since my blood tests were all normal. I have to go back in 2 weeks and they scheduled anther EMG not due until March, can you believe that ?

Anyhow, I'm new to this forum and just wanted to get some feed back on what people feel with peripheral neuropathy ?

My ankles feel like they are sprained at times when I walk when they are not, I get strange feeling up into my calf muscle pains like its going to cramp but never does. Bottoms of my feet feel like I'm walking on sand and pebbles. they've been like that for years but not this bad. I can do heel and toe raises but it hurts to push off from my toes due to the fat pad atrophy from all the years of running playing tennis and hiking I suppose.

I feel as though I cannot build muscle in my legs anymore even though I go the PT 3 days a week for my knee.

Would PN cause muscle tone loss ?