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Old 03-15-2016, 09:19 AM #1
stillHoping stillHoping is offline
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But doesn't the neurotransmission only happen from the spinal cord and out? I don't know. I'm just trying to learn all about this.
No, the neurotransmitters are used in the communications between the nerves themselves and between the nerves and the target organs (e.g. muscles, internal organs etc.). For example the neurotransmitter Acetyl choline (ACh) is used in the synapses between the nerves and the skeletal muscles, and these synapses are adjacent to the muscles throughout the body. The same goes for the autonomic innervations of the internal organs which are mostly done with the neurotransmitters ACh and Norepinephrine.
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glenntaj (03-16-2016)
Old 03-15-2016, 10:00 AM #2
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No, the neurotransmitters are used in the communications between the nerves themselves and between the nerves and the target organs (e.g. muscles, internal organs etc.). For example the neurotransmitter Acetyl choline (ACh) is used in the synapses between the nerves and the skeletal muscles, and these synapses are adjacent to the muscles throughout the body. The same goes for the autonomic innervations of the internal organs which are mostly done with the neurotransmitters ACh and Norepinephrine.
So than why would they prescribe a drug like mestinon when someone could just take citicholine?
I am actually getting ready to try the supplement, but due to an asthma flare, I am hesitant to start anything new.
Forgive my questions, but I am still learning and the doctors explain nothing.
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Old 03-15-2016, 01:33 PM #3
stillHoping stillHoping is offline
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So than why would they prescribe a drug like mestinon when someone could just take citicholine?
I am actually getting ready to try the supplement, but due to an asthma flare, I am hesitant to start anything new.
Forgive my questions, but I am still learning and the doctors explain nothing.
Citicoline or choline ?

I know a little about Mestinon and haven’t heard about Citicoline ,so as far as I understand from googling….
Mestinon doesn’t cross the blood brain barrier (BBB) and it increases the effects of the neurotransmitter ACh in the nervous system throughout the body, but not in the brain. And this is probably the desired effect in peripheral neuropathy.
Choline might also increase the ACh signal (in different mechanism than mestinon), but it is involved in some other processes in the body, and it can pass the BBB, so it is less specific than the Mestinon and can affect the brain.
As far as I understand from googling and wiki, Citicoline pass the BBB and it is even less specific than choline.

Regarding the doctors that explain nothing.... I am extremely frustrated from this too....
I wish there was a treatment that can improve their communication skills and empathy...
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madisongrrl (10-06-2017)
Old 03-15-2016, 01:57 PM #4
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Originally Posted by stillHoping View Post
Citicoline or choline ?

I know a little about Mestinon and haven’t heard about Citicoline ,so as far as I understand from googling….
Mestinon doesn’t cross the blood brain barrier (BBB) and it increases the effects of the neurotransmitter ACh in the nervous system throughout the body, but not in the brain. And this is probably the desired effect in peripheral neuropathy.
Choline might also increase the ACh signal (in different mechanism than mestinon), but it is involved in some other processes in the body, and it can pass the BBB, so it is less specific than the Mestinon and can affect the brain.
As far as I understand from googling and wiki, Citicoline pass the BBB and it is even less specific than choline.

Regarding the doctors that explain nothing.... I am extremely frustrated from this too....
I wish there was a treatment that can improve their communication skills and empathy...
The one I got is called citicoline "cdp coline", it says it is from stabilized cytidine 5' disphosphocholine.... what ever that means.

Heck, I honesty could care less about the empathy especially if I could find a truly intelligent motivated doctor who was more than just good at memorizing the text books to pass their exams.
I am amazed at how much more I know already about certain medical topics from my research on pubmed than most of the doctors I see.
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Old 10-01-2017, 12:22 PM #5
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I've never taken gabapentin but know people who have and NOW off it and did suffer with enough side effects. I've been using Gaba as part of my sleep combo and thinking gaba could be helping with nerve damage. I deal with damage from hip replacement where I ended up with a lot of femoral nerve damage which has caused issues down my whole right side into my foot.

Is There Any Difference Between GABA and Gabapentin? | gammaaminobutyricacid.org
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