Does anyone know how long you should wait in between skin biopsies to see if there is any change? My results at both ankle and thigh were zero 4 months ago. Thanks!

Summerfun - I am no expert here but I think usually people wait a little longer for repeat testing. I am also curious about this actually. I got my first biopsy 3.5 years ago and since have seen slowly worsening in symptoms...thinking it is time to see if a biopsy proves what I am feeling....

Why do you want to repeat it ?
Have you got any treatment that suppose to regenerate the nerves ?

As Stillhoping asked...why do you want to repeat it? In most cases, the biopsy is repeated AFTER the use of a treatment that has hopes of increasing density or repairing nerves...like IVIG.

Even if you did have a treatment that may change your biopsy results, you should wait at least 6-9 months...sometimes longer...all depending on the what treatment you have been using.

Can you give us a little more information, so we can better answer your question??

Thanks everyone. No I am not receiving treatment. On Gabapentin. While still working with idiopathic diagnosis it is leaning toward a post infectious cause either directly related to the pathogen or molecular mimicry. From reading these posts it seems there might be hope for slow recovery in these cases. I was just wondering how long it would be until improvement started to show IF it were going to improve. Just thought (hoping) a skin biopsy might show slight improvement. Neuropathy started August, 2014. No change in pain level since it started.

I honestly don't think you'll see a huge difference in just 4 months. Nerves take a very long time to heal...it's a SLOW process.

When there is an improvement due to treatment, how long does it take to feel it and to see a difference in the biopsy ?

--that if one is getting improvement (slow nerve regeneration), one might have trouble distinguishing initially, as often the process of small fiber nerve growth cones fighting past and through other tissue can produce parastheses and other weird sensations that might well make one think that one is actually having a flare or getting worse.

In long term retrospect, though, if one is getting regeneration these sensations usually calm as the brain gets used to interpreting signals coming from the new connections. But that may take months or longer.

I would think, given the really slow rate of nerve regeneration even under the best of conditions, one shouldn't rely on seeing different skin biopsy results month to month. Annual repetition seems a good interval (unless one is convinced one is having an acute process that is getting rapidly WORSE).

Makes sense. Very helpful information. When I have a flare, I will think positive and say to myself "I am getting better." . I wish everyone a good and pain free day!

Would you mind if I ask questions? I was diagnosed at the end of 2014 after experiencing mostly autonomic symptoms that began to turn into nerve pain, numbness, tingling, etc. I wound up so bad I could barely function for 6 months. I have recovered somewhat.
Do you remember having the virus?
How did your neuropathy start- what symptoms, how did it progress?
What are your symptoms now?